This chapter shows how conflict between the American hegemon and a rising China led to the collapse of the Doha Round (2001–11) and the breakdown of the WTO’s core negotiation function. At the center of the Doha standoff, I argue, is a dispute between the US and China centered on how China should be treated in the multilateral trading system. China has maintained that, as a developing country, it should be entitled to the special and differential treatment (SDT) promised to developing countries. The US, however, is unwilling to extend such treatment to its chief rival, and therefore refused to conclude the round without greater market opening from China. China rejected American demands that it undertake additional liberalization concessions, and, in doing so, showed that it has sufficient power to refuse to concede to US demands that it views as fundamentally against its own development interests. The US has a long track record of successfully overpowering opposition in multilateral trade negotiations and securing assent for its desired outcomes. Yet, in contrast with the past, the US has been unable to overpower China, and this deep and lasting impasse between the two powers resulted in the collapse of the Doha Round.