Drug-induced seizures can arise in the setting of acute drug withdrawal or drug toxicity, or as a consequence of medication use for acute illness in patients with no prior history of seizures. It has been long recognized that the antidepressants cause drug-induced seizures by lowering seizure threshold particularly at supratherapeutic levels. Seizures have been reported with several classes of antibiotics particularly the penicillins, the cephalosporins, the carbapanems, and the fluoroquinolones. Reational drugs can cause seizures, in particular cocaine and the stimulants like amphetamines and phencyclidine. A review of clinical trial data provided by the manufacturers of three new antiepileptic drugs (AEDs), tiagabine, topiramate, and levetiracetam has been carried out to determine whether a paradoxical increase in seizure frequency was more likely on an AED compared to placebo. A doubling of seizure frequency was more likely with patients taking placebo but this did not reach statistical significance.