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Case 20 - Treatment-resistant depression and opioid dependence

Published online by Cambridge University Press:  19 October 2021

Takesha Cooper
Affiliation:
University of California, Riverside
Gerald Maguire
Affiliation:
University of California, Riverside
Stephen Stahl
Affiliation:
University of California, San Diego
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Summary

Pretest self-assessment question (answer at the end of the case)

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Publisher: Cambridge University Press
Print publication year: 2021

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References

Berman, RM, Cappiello, A, Anand, A, et al. Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 2000; 47:351–4. https://doi.org/10.1016/s0006-3223(99)00230-9CrossRefGoogle ScholarPubMed
Deyama, S, Bang, E, Wohleb, ES, et al. Role of neuronal VEGF signaling in the prefrontal cortex in the rapid antidepressant effects of ketamine. Am J Psychiatry 2019; 176:388–40. https://doi.org/10.1176/appi.ajp.2018.17121368CrossRefGoogle ScholarPubMed
Duman, R, Li, N, Liu, R, et al. Signaling pathways underlying the rapid antidepressant actions of ketamine. Neuropharmacology 2012; 62:3541. https://doi.org/10.1016/j.neuropharm.2011.08.044CrossRefGoogle ScholarPubMed
Heifets, BD, Williams, NR, Blasey, C, et al. Interpreting ketamine’s opioid receptor dependent effect: response to Sanacora. Am J Psychiatry 2019; 176:249–50. https://doi.org/10.1176/appi.ajp.2018.18091061rCrossRefGoogle ScholarPubMed
Jacobson, ML, Simmons, SC, Wulf, HA, et al. Protracted effects of ketamine require immediate kappa opioid receptor activation and long-lasting desensitization. FASEB J 2020; 34: 1. https://doi.org/10.1096/fasebj.2020.34.s1.04214CrossRefGoogle Scholar
Klein, ME, Chandra, J, Sheriff, S, Malinow, R. Opioid system is necessary but not sufficient for antidepressive actions of ketamine in rodents. Proc Natl Acad Sci U S A 2020; 117:2656–62. https://doi.org/10.1073/pnas.1916570117CrossRefGoogle Scholar
Mathew, SJ, Rivas-Grajales, AM. Does the opioid system block or enhance the antidepressant effects of ketamine? Chronic Stress (Thousand Oaks) 2019; 3: 2470547019852073. https://doi.org/10.1177/2470547019852073Google ScholarPubMed
Raehal, KM, Lowery, JJ, Bhamidipati, CM, et al. In vivo characterization of 6β-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice. J Pharmacol Exp Ther 2005; 313:1150–62. https://doi.org/10.1124/jpet.104.082966CrossRefGoogle ScholarPubMed
Sanacora, G. Caution against overinterpreting opiate receptor stimulation as mediating antidepressant effects of ketamine. Am J Psychiatry 2019; 176:249. https://doi.org/10.1176/appi.ajp.2018.18091061CrossRefGoogle ScholarPubMed
Scheuing, L, Chiu, C-T, Liao, H-M, Chuang, D-M. Antidepressant mechanism of ketamine: perspective from preclinical studies. Front Neurosci 2015; 9:249. https://doi.org/10.3389/fnins.2015.00249CrossRefGoogle ScholarPubMed
Shader, R. Antagonists, inverse agonists, and protagonists. J Clin Psychopharmacol 2003; 23:321–2. https://doi.org/10.1097/01.jcp.0000087502.38434.6cCrossRefGoogle ScholarPubMed
Stahl, SM. Stahl’s Essential Psychopharmacology, 4th edn. New York, NY: Cambridge University Press, 2013.Google Scholar
Stahl, SM. Stahl’s Essential Psychopharmacology: The Prescriber’s Guide, 6th edn. Cambridge, UK: Cambridge University Press, 2017.Google Scholar
Wang, M, Kaplin, A. Explaining naltrexone’s interference with ketamine’s antidepressant effect. Am J Psychiatry 2019; 176:410–11. https://doi.org/10.1176/appi.ajp.2019.19010044CrossRefGoogle ScholarPubMed
Williams, NR, Heifets, BD, Blasey, C, et al. Attenuation of antidepressant effects of ketamine by opioid receptor antagonism. Am J Psychiatry 2018; 175:1205–15.CrossRefGoogle ScholarPubMed

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