Skip to main content Accessibility help
×
Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-19T13:40:53.045Z Has data issue: false hasContentIssue false

Case 6: - The man whom clozapine (Clozaril) could not touch

Published online by Cambridge University Press:  03 April 2024

Nevena V. Radonjić
Affiliation:
State University of New York Upstate Medical University
Thomas L. Schwartz
Affiliation:
State University of New York Upstate Medical University
Stephen M. Stahl
Affiliation:
University of California, San Diego
Get access

Summary

Which of the following is true regarding clozapine (Clozaril) dosing?

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2024

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ashton, AK. Aripiprazole augmentation of clozapine: in refractory schizophrenia. Psychiatry (Edgmont) 2005; 2:1819Google ScholarPubMed
Butler, MG. Pharmacogenetics and psychiatric care: a review and commentary. J Ment Health Clin Psychol 2018; 2:1724CrossRefGoogle Scholar
Dhillon, N, Heun, R. Nocturnal enuresis is an under-recognised side effect of clozapine: results of a systematic review. Global Psychiatry 2019; 2:2130Google Scholar
Ellison, JC, Dufresne, RL. A review of the clinical utility of serum clozapine and norclozapine levels. Ment Health Clin 2015; 5:6873CrossRefGoogle Scholar
Gee, S, Howes, O. Optimising treatment of schizophrenia: the role of adjunctive fluvoxamine. Psychopharmacology 2016; 233:739–40CrossRefGoogle ScholarPubMed
Gray, J, Risch, S. When clozapine is not enough: augment with lamotrigine? Curr Psychiatry 2009; 8:40–6Google Scholar
Hinze-Selch, D, Deuschle, M, Weber, B, et al. Effect of coadministration of clozapine and fluvoxamine versus clozapine monotherapy on blood cell counts, plasma levels of cytokines and body weight. Psychopharmacology (Berl) 2000; 149:163–9CrossRefGoogle ScholarPubMed
Kane, JM, Agid, O, Baldwin, ML, et al. Clinical guidance on the identification and management of treatment-resistant schizophrenia. J Clin Psychiatry 2019; 80(2):18com12123CrossRefGoogle ScholarPubMed
Lammers, CH, Deuschle, M, Weigmann, H, et al. Coadministration of clozapine and fluvoxamine in psychotic patients – clinical experience. Pharmacopsychiatry 1999; 32:76–7CrossRefGoogle ScholarPubMed
Lu, ML, Lane, HY, Chen, KP, et al. Fluvoxamine reduces the clozapine dosage needed in refractory schizophrenic patients. J Clin Psychiatry 2000; 61:594–9CrossRefGoogle ScholarPubMed
Lu, ML, Lane, HY, Lin, SK, et al. Adjunctive fluvoxamine inhibits clozapine-related weight gain and metabolic disturbances. J Clin Psychiatry 2004; 65:766–71CrossRefGoogle ScholarPubMed
Meyer, JM, Proctor, G, Cummings, MA, et al. Ciprofloxacin and clozapine: a potentially fatal but underappreciated interaction. Case Rep Psychiatry 2016; 2016:5606098Google ScholarPubMed
Meyer, JM, Stahl, SM. The Clozapine Handbook, Cambridge: Cambridge University Press, 2019CrossRefGoogle Scholar
Olsson, E, Edman, G, Bertilsson, L, et al. Genetic and clinical factors affecting plasma clozapine concentration. Prim Care Companion CNS Disord 2015; 17(1):10.4088/PCC.14m01704Google ScholarPubMed
Polcwiartek, C, Nielsen, J. The clinical potentials of adjunctive fluvoxamine to clozapine treatment: a systematic review. Psychopharmacology 2016; 233:741–50CrossRefGoogle ScholarPubMed
Schwartz, D. Interpretation of clozapine levels. Graylands Hospital Drug Bulletin 2017; 24:18Google Scholar
Stahl, SM. Stahl’s Essential Psychopharmacology: Prescriber’s Guide, 5. Cambridge: Cambridge University Press, 2017Google Scholar
Stahl, SM. Transporters, Receptors, and Enzymes as Targets of Psychopharmacological Drug Action, 5. Cambridge: Cambridge University Press, 2021Google Scholar
Stahl, SM, Schwartz, T. Case Studies: Stahl’s Essential Psychopharmacology. Cambridge: Cambridge University Press, 2016CrossRefGoogle Scholar
Tanzer, T, Warren, N, McMahon, L, et al. Treatment strategies for clozapine-induced nocturnal enuresis and urinary incontinence: a systematic review. CNS Spectr 2022; 28(2):13344CrossRefGoogle Scholar
Wigard, ME, van Gool, AR, Schulte, PF. Addition of fluvoxamine to clozapine: theory and practice. Tijdschr Psychiatr 2013; 55:113–21Google ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×