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Case 1: The salutatorian who couldn’t speak: selective serotonin reuptake inhibitor (SSRI)-refractory anxiety in an adolescent

Published online by Cambridge University Press:  09 February 2024

Jeffrey R. Strawn  and
Stephen M. Stahl
Jeffrey R. Strawn
Affiliation:
University of Cincinnati, Ohio
Stephen M. Stahl
Affiliation:
University of California, San Diego
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Summary

Which of the following represents an evidence-based intervention for a patient with treatment-resistant anxiety?

Type
Chapter
Information
Case Studies: Stahl's Essential Psychopharmacology
Children and Adolescents
 , pp. 1 - 16
Publisher: Cambridge University Press
Print publication year: 2023

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References

Aldrich, S. L., Poweleit, E. A., Prows, C. A., et al. Influence of CYP2C19 metabolizer status on escitalopram/citalopram tolerability and response in youth with anxiety and depressive disorders. Front Pharmacol 2019; 10: 99. https://doi.org/10.3389/fphar.2019.00099Google Scholar
Chugani, D. C., Muzik, O., Juhász, C., et al. Postnatal maturation of human GABAA receptors measured with positron emission tomography. Ann Neurol 2001; 49: 618–26. https://doi.org/10.1002/ana.1003Google Scholar
Compton, S. N., Peris, T. S., Almirall, D., et al. Predictors and moderators of treatment response in childhood anxiety disorders: results from the CAMS trial. J Consult Clin Psychol 2014; 82: 212–24. https://doi.org/10.1037/a0035458Google Scholar
Dobson, E. T., Bloch, M. H., Strawn, J. R. Efficacy and tolerability of pharmacotherapy for pediatric anxiety disorders: a network meta-analysis. J Clin Psychiatry 2019; 80: 17r12064. https://doi.org/10.4088/JCP.17r12064Google Scholar
Greenblatt, D. J., Allen, M. D., Harmatz, J. S., Shader, R. I. Diazepam disposition determinants. Clin Pharmacol Ther 1980; 27: 301–12. https://doi.org/10.1038/clpt.1980.40Google Scholar
Kupferschmidt, H. H., Ha, H. R., Ziegler, W. H., Meier, P. J., Krähenbühl, S. Interaction between grapefruit juice and midazolam in humans. Clinical Pharmacol Ther 1995; 58: 20–28. https://doi.org/10.1016/0009-9236(95)90068-3Google Scholar
Locher, C., Koechlin, H., Zion, S. R., et al. Efficacy and safety of selective serotonin reuptake inhibitors, serotonin–norepinephrine reuptake inhibitors, and placebo in common psychiatric disorders: a meta-analysis in children and adolescents. JAMA Psychiatry 2017; 74: 1011–20. https://doi.org/10.1001/jamapsychiatry.2017.2432CrossRefGoogle ScholarPubMed
Peris, T. S., Sugar, C. A., Lindsey Bergman, R., et al. Family factors predict treatment outcome for pediatric obsessive compulsive disorder. J Consult Clin Psychol 2012; 80: 255–63. https://doi.org/10.1037/a0027084CrossRefGoogle ScholarPubMed
Peris, T. S., Compton, S. N., Kendall, P. C., et al. Trajectories of change in youth anxiety during cognitive–behavior therapy. J Consult Clin Psychol 2015; 83: 239–52. https://doi.org/10.1037/a0038402Google Scholar
Peris, T. S., Caporino, N. E., O’Rourke, S., et al. Therapist-reported features of exposure tasks that predict differential treatment outcomes for youth with anxiety. J Am Acad Child Adolesc Psychiatry 2017; 56: 1043–52. https://doi.org/10.1016/j.jaac.2017.10.001Google Scholar
Stahl, S., Grady, M. M., Muntner, N. Stahl’s Essential Psychopharmacology: Neuroscientific Basis and Practical Applications, 5th edn. Cambridge, UK: Cambridge University Press, 2021.Google Scholar
Strawn, J. R., Stimpfl, J. Practical pharmacology: optimizing benzodiazepine treatment in anxiety disorders. Current Psychiatry 2023; in press.Google Scholar
Strawn, J. R., Prakash, A., Zhang, Q., et al. A randomized, placebo-controlled study of duloxetine for the treatment of children and adolescents with generalized anxiety disorder. J Am Acad Child Adolesc Psychiatry 2015; 54: 283–93. https://doi.org/10.1016/j.jaac.2015.01.008Google Scholar
Strawn, J. R., Compton, S. N., Robertson, B., et al. Extended release guanfacine in pediatric anxiety disorders: a pilot, randomized, placebo-controlled trial. J Child Adolesc Psychopharmacol 2017; 27: 29–37. https://doi.org/10.1089/cap.2016.0132Google Scholar
Strawn, J. R., Geracioti, L., Rajdev, N., Clemenza, K., Levine, A. Pharmacotherapy for generalized anxiety disorder in adults and pediatric patients: an evidence-based treatment review. Expert Opin Pharmacother 2018a; 19: 1057–70. https://doi.org/10.1080/14656566.2018.1491966Google Scholar
Strawn, J. R., Mills, J. A., Sauley, B. A., Welge, J. A. The impact of antidepressant dose and class on treatment response in pediatric anxiety disorders: a meta-analysis. J Am Acad Child Adolesc Psychiatry 2018b; 57: 235–44.e2. https://doi.org/10.1016/j.jaac.2018.01.015Google Scholar
Strawn, J. R., Mills, J. A., Schroeder, H., et al. Escitalopram in adolescents with generalized anxiety disorder: a double-blind, randomized, placebo-controlled study. J Clin Psychiatry 2020; 81: 20m13396. https://doi.org/10.4088/JCP.20m13396Google Scholar
Strawn, J. R., Lu, L., Peris, T. S., Levine, A., Walkup, J. T. Research review: pediatric anxiety disorders – what have we learnt in the last 10 years? J Child Psychol Psychiatry 2021; 62: 114–39. https://doi.org/10.1111/jcpp.13262Google Scholar
Walkup, J. T., Albano, A. M., Piacentini, J., et al. Cognitive behavioral therapy, sertraline, or a combination in childhood anxiety. N Engl J Med 2008; 359: 2753–66. https://doi.org/10.1056/NEJMoa0804633Google Scholar
Williams, T., Hattingh, C. J., Kariuki, C. M., et al. Pharmacotherapy for social anxiety disorder (SAnD). Cochrane Database Syst Rev 2017; 10: CD001206. https://doi.org/10.1002/14651858.CD001206.pub3Google Scholar

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