This chapter presents the pharmacologic management of a case of convulsive status epilepticus. Nonconvulsive status epilepticus can be accompanied by abnormal mental status, unresponsiveness, ocular motor abnormalities, and persistent subclinical seizures. Status epilepticus is a life-threatening condition that requires immediate identification and treatment. Patients with refractory status epilepticus who have not responded to the first-line treatment will require admission to the intensive care unit (ICU) for more aggressive management. Tracheal intubation and controlled mechanical ventilation with the use of muscle relaxants are the first steps in intensive care management of refractory status epilepticus. The pharmacokinetics and favorable adverse effect profile make propofol drug to treat refractory status epilepticus. Surgical intervention can be considered as a last resort in patients who failed medical treatment and have a lesion amenable to surgery. There are different strategies to treat status epilepticus, such as lorazepam, fosphenytoin or phenytoin and propofol or phenobar.