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Chapter 1 - Fertility Assessment and Fertility Preservation Options

Published online by Cambridge University Press:  23 October 2024

By
Anna Claire Reynolds ,
Terri L. Woodard  and
Laurie J. McKenzie
Edited by
Laurie J. Mckenzie  and
Denise R. Nebgen
Laurie J. Mckenzie
Affiliation:
University of Texas MD Anderson Cancer Center, Houston
Denise R. Nebgen
Affiliation:
University of Texas MD Anderson Cancer Center, Houston
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Summary

Approximately 10% of women diagnosed with cancer are of reproductive age. As survival rates improve, there is an increased focus on the complex issues surrounding cancer survivorship, particularly for younger women of reproductive age. Among young women diagnosed with cancer, concerns regarding future fertility are secondary only to concerns regarding survival. Guidelines from the American Society of Clinical Oncology (ASCO) and American Society for Reproductive Medicine (ASRM) state that healthcare providers should discuss the risk of infertility and fertility preservation options with all reproductive age patients diagnosed with cancer. This chapter reviews the proposed mechanisms of chemotherapy induced ovarian toxicity and how to assess baseline ovarian reserve. Fertility preservation options are discussed, including medical and conservative surgical management for select patients with gynecologic malignancies, oocyte and embryo cryopreservation, ovarian tissue cryopreservation and ovarian suppression. Data regarding the safety of ovarian stimulation and subsequent pregnancy are included.

Keywords

Oncofertilityfertility preservationfertility assessmentovarian reserveovarian toxicity
Type
Chapter
Information
Caring for the Female Cancer Patient
Gynecologic Considerations
 , pp. 1 - 23
Publisher: Cambridge University Press
Print publication year: 2024

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