Book contents
- Cardiopulmonary Bypass
- Cardiopulmonary Bypass
- Copyright page
- Contents
- Contributors
- Foreword
- Chapter 1 Human Factors and Teamwork in Cardiac Surgery
- Chapter 2 Equipment for Cardiopulmonary Bypass
- Chapter 3 Monitoring during Cardiopulmonary Bypass
- Chapter 4 Cardiopulmonary Bypass Circuit Setup and Safety Checks
- Chapter 5 Priming Solutions for Cardiopulmonary Bypass Circuits
- Chapter 6 Anticoagulation for Cardiopulmonary Bypass
- Chapter 7 Conduct of Cardiopulmonary Bypass
- Chapter 8 Minimal Invasive Extracorporeal Circulation
- Chapter 9 Considerations for Operations Involving Deep Hypothermic Circulatory Arrest
- Chapter 10 Metabolic Management during Cardiopulmonary Bypass
- Chapter 11 Myocardial Preservation during Cardiopulmonary Bypass
- Chapter 12 Weaning from Cardiopulmonary Bypass
- Chapter 13 Intraoperative Mechanical Circulatory Support and Other Uses of Cardiopulmonary Bypass
- Chapter 14 Mechanical Circulatory Support
- Chapter 15 Cardiopulmonary Bypass for Pediatric Cardiac Surgery
- Chapter 16 Coagulopathy and Hematological Disorders Associated with Cardiopulmonary Bypass
- Chapter 17 Inflammation and Organ Damage during Cardiopulmonary Bypass
- Chapter 18 Neuromonitoring and Cerebral Morbidity Associated with Cardiopulmonary Bypass
- Chapter 19 Renal Morbidity Associated with Cardiopulmonary Bypass
- Chapter 20 Common and Uncommon Disasters during Cardiopulmonary Bypass
- Index
- References
Chapter 17 - Inflammation and Organ Damage during Cardiopulmonary Bypass
Published online by Cambridge University Press: 24 October 2022
Book contents
- Cardiopulmonary Bypass
- Cardiopulmonary Bypass
- Copyright page
- Contents
- Contributors
- Foreword
- Chapter 1 Human Factors and Teamwork in Cardiac Surgery
- Chapter 2 Equipment for Cardiopulmonary Bypass
- Chapter 3 Monitoring during Cardiopulmonary Bypass
- Chapter 4 Cardiopulmonary Bypass Circuit Setup and Safety Checks
- Chapter 5 Priming Solutions for Cardiopulmonary Bypass Circuits
- Chapter 6 Anticoagulation for Cardiopulmonary Bypass
- Chapter 7 Conduct of Cardiopulmonary Bypass
- Chapter 8 Minimal Invasive Extracorporeal Circulation
- Chapter 9 Considerations for Operations Involving Deep Hypothermic Circulatory Arrest
- Chapter 10 Metabolic Management during Cardiopulmonary Bypass
- Chapter 11 Myocardial Preservation during Cardiopulmonary Bypass
- Chapter 12 Weaning from Cardiopulmonary Bypass
- Chapter 13 Intraoperative Mechanical Circulatory Support and Other Uses of Cardiopulmonary Bypass
- Chapter 14 Mechanical Circulatory Support
- Chapter 15 Cardiopulmonary Bypass for Pediatric Cardiac Surgery
- Chapter 16 Coagulopathy and Hematological Disorders Associated with Cardiopulmonary Bypass
- Chapter 17 Inflammation and Organ Damage during Cardiopulmonary Bypass
- Chapter 18 Neuromonitoring and Cerebral Morbidity Associated with Cardiopulmonary Bypass
- Chapter 19 Renal Morbidity Associated with Cardiopulmonary Bypass
- Chapter 20 Common and Uncommon Disasters during Cardiopulmonary Bypass
- Index
- References
Summary
The transition from physiological circulation to cardiopulmonary bypass (CPB) represents a major change to the homeostasis of the body including alterations in the distribution of blood flow and oxygen delivery to organs, which may at least in part account for the organ dysfunction during CPB. Layered on top of disturbances in oxygen delivery is a systemic inflammatory response triggered by contact of leukocytes and other blood components with the artificial surfaces of the extracorporeal circuit. While most of these host responses are appropriate and desirable in the context of a localized injury or infection, they are not desirable systemically and contribute to the morbidity and mortality associated with cardiopulmonary bypass.
Keywords
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- Cardiopulmonary Bypass , pp. 166 - 174Publisher: Cambridge University PressPrint publication year: 2022
References
Suggested Further Reading
Prondzinsky, R, Knupfer, A, Loppnow, H et al. Surgical trauma affects the proinflammatory status after cardiac surgery to a higher degree than cardiopulmonary bypass. J Thorac Cardiovasc Surg 2005 April;129(4):760–766.CrossRefGoogle ScholarPubMed
Dieleman, JM, van Passen, J, van Dijk, D et al. Prophylactic corticosteroids for cardiopulmonary bypass in adults. Cochrane Database Syst Rev 2011;(5):CD005566.Google Scholar
Warren, O, Alexiou, C, Massey, R et al. The effects of various leukocyte filtration strategies in cardiac surgery. Eur J Cardiothorac Surg 2007 April;31(4):665–676.CrossRefGoogle ScholarPubMed
Zhu, X, Ji, B, Wang, G et al. The effects of zero-balance ultrafiltration on postoperative recovery after cardiopulmonary bypass: a meta-analysis of randomized controlled trials. Perfusion 2012 September;27(5):386–392.CrossRefGoogle ScholarPubMed
Ranucci, M, Balduini, A, Ditta, A et al. A systematic review of biocompatible cardiopulmonary bypass circuits and clinical outcome. Ann Thorac Surg 2009 April;87(4):13111319.CrossRefGoogle ScholarPubMed
De, Backer D, Dubois, MJ, Schmartz, D et al. Microcirculatory alterations in cardiac surgery: effects of cardiopulmonary bypass and anesthesia. Ann Thorac Surg 2009 November;88(5):13961403.Google Scholar
Litmathe, J, Boeken, U, Bohlen, G et al. Systemic inflammatory response syndrome after extracorporeal circulation: a predictive algorithm for the patient at risk. Hellenic J Cardiol 2011 November;52(6):493–500.Google Scholar
Hessel, EA 2nd. Abdominal organ injury after cardiac surgery. Semin Cardiothorac Vasc Anesth, 2004. 8(3):243–263.CrossRefGoogle ScholarPubMed
Weissman, C. Pulmonary complications after cardiac surgery. Semin Cardiothorac Vasc Anesth 2004. 8(3):185–211.CrossRefGoogle ScholarPubMed
Buggeskov, KB, Grønlykke, L, Risom, EC et al. Pulmonary artery perfusion versus no perfusion during cardiopulmonary bypass for open heart surgery in adults. Cochrane Database Syst Rev 2018 February 8;2:CD011098.Google Scholar
Ng, CS, Wan S., Limiting inflammatory response to cardiopulmonary bypass: pharmaceutical strategies. Curr Opin Pharmacol 2012. 12(2):155–159.CrossRefGoogle ScholarPubMed
Dvirnik, N, Belley-Cote, E, Hanif, H et al. Steroids in cardiac surgery: a systematic review and meta-analysis. Br J Anesth 2018 120 (4): 657–667.Google Scholar
Butler, J, Rocker, GM, Westaby, S.
Inflammatory response to cardiopulmonary bypass. Ann Thorac Surg
1993 February;55(2):552–9.Google Scholar
Landis, RC, Arrowsmith, JE, Baker, RA, et al.
Consensus Statement: minimal criteria for reporting the systemic inflammatory response to cardiopulmonary bypass. Heart Surg Forum
2010 April;13(2) E116–123.Google Scholar
Shann, KG, Likosky, DS, Murkin, JM, et al. An evidence-based review of the practice of cardiopulmonary bypass in adults: a focus on neurologic injury, glycemic control, hemodilution, and the inflammatory response. J Thorac Cardiovasc Surg 2006 August;132(2):283–90.Google Scholar
Landis, RC, Brown, JR, Fitzgerald, D, et al. Attenuating the Systemic Inflammatory Response to Adult Cardiopulmonary Bypass: A critical Review of the Evidence Base. J Extra Corpor Technol 2014 September;46(3):197–211.Google Scholar
Myers, GJ, Wegner, J. Endothelial Glycocalyx and Cardiopulmonary Bypass. J Extra Corpor Technol 2017 September;49(3):174–181.CrossRefGoogle ScholarPubMed
Landis, RC, Durandy, Y “Dear SIRS … unfaithfully yours”. Anaesth Intensive Care 2017 March;45(2):274–275.Google ScholarPubMed