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8 - Pain syndromes in cancer survivors

from SECTION III - ASSESSMENT

Published online by Cambridge University Press:  06 July 2010

By
ROSEMARY C. POLOMANO ,
MICHAEL ASHBURN  and
JOHN T. FARRAR
Edited by
Eduardo D. Bruera  and
Russell K. Portenoy
ROSEMARY C. POLOMANO
Affiliation:
The University of Pennsylvania
MICHAEL ASHBURN
Affiliation:
The University of Pennsylvania
JOHN T. FARRAR
Affiliation:
The University of Pennsylvania
Eduardo D. Bruera
Affiliation:
University of Texas, Houston
Russell K. Portenoy
Affiliation:
Albert Einstein College of Medicine, New York
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Summary

Introduction

Over the past decades, aggressive therapies for cancer have led to improved statistics for long-term survival. From 1996 to 2002, the 5-year survival rate for all cancers was 66%, which represents a significant increase from 51% in the short span between 1975 to 1977. Although 5-year survival rates do not represent the numbers of patients who are cured from cancer, it is an indicator that many cancer patients are living longer. The actual numbers of cancer survivors in the U.S. populace remain unknown, but reported estimates are in the range of 10 million to 12 million. It is anticipated that life expectancies after a cancer diagnosis will continue to increase with new developments in cancer treatments. With increasingly aggressive therapies, survivors may face more residual problems that will ultimately affect their ongoing level of functioning, quality of life (QOL), and need for health care.

Limited research has been conducted on cancer survivors relative to the large numbers of studies of patients actively undergoing treatment for cancer. As such, it is impossible to obtain precise estimates of the number of survivors with chronic problems as a result of their disease or its treatment, such as pain. Issues related to cancer survivorship have recently been brought to the national forefront. The American Journal of Nursing and the National Cancer Institute sponsored a consensus conference in July 2005.

Type
Chapter
Information
Cancer Pain
Assessment and Management
 , pp. 145 - 164
Publisher: Cambridge University Press
Print publication year: 2009

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References

,American Cancer Society. Cancer facts and figures 2007. Atlanta: American Cancer Society, 2007. Available at: http://www.cancer.org/downloads/STT/CAFF2007PWSecured.pdf. Accessed November 12, 2007.Google Scholar
Parker, SL, Tong, T, Bolden, S, Wingo, PA. Cancer statistics, 1997. CA Cancer J Clin 47:5–27, 1997.CrossRefGoogle ScholarPubMed
Edwards, BK, Howe, HL, Ries, , et al. Annual report to the nation on the status of cancer, 1973–1999, featuring implications of age and aging on U.S. cancer burden. Cancer 94:2766–92, 2002.CrossRefGoogle ScholarPubMed
Rowland, J, Mariotto, A, Aziz, N, et al. Cancer survivorship – United States, 1971–2001. MMWR Morb Mortal Wkly Rep 53:526–9, 2004.Google Scholar
Travis, LB, Rabkin, CS, Brown, LM, et al. Cancer survivorship – genetic susceptibility and second primary cancers: research strategies and recommendations. J Natl Cancer Inst 98:15–25, 2006.CrossRefGoogle ScholarPubMed
Polomano, RC, Farrar, JT. Pain and neuropathy in cancer survivors. Surgery, radiation, and chemotherapy can cause pain; research could improve its detection and treatment. Am J Nurs 106(3 Suppl):39–47, 2006.CrossRefGoogle Scholar
,Institute of Medicine of the National Academies. Implementing cancer survivorship care planning: workshop summary. Available at: http://www.iom.edu/CMS/26765/39416.aspx. Accessed November 14, 2007.
,Institute of Medicine of the National Academies. From cancer to cancer survivor: lost in transition. Institute of Medicine of the National Academies report, November 7, 2005. Available at: http://www.iom.edu/CMS/28312/4931/30869.aspx. Accessed November 14, 2007.
,National Cancer Institute. Dictionary of cancer terms; survivorship. Available at: http://www.cancer.gov/Templates/db_alpha.aspx?CdrID=445089. Accessed November 14, 2007.
Mao, JJ, Armstrong, K, Bowman, MA, et al. Symptom burden among cancer survivors: impact of age and comorbidity. J Am Board Fam Med 20:434–43, 2007.CrossRefGoogle ScholarPubMed
Keating, NL, Norredam, M, Landrum, MB, et al. Physical and mental health status of older long-term cancer survivors. J Am Geriatr Soc 53:2145–52, 2005.CrossRefGoogle ScholarPubMed
Mols, F, Coebergh, JW, Poll-Franse, LV. Health-related quality of life and health care utilisation among older long-term cancer survivors: a population-based study. Eur J Cancer 43:2211–21, 2007.CrossRefGoogle ScholarPubMed
Foley, KL, Farmer, DF, Petronis, VM, et al. A qualitative exploration of the cancer experience among long-term survivors: comparisons by cancer type, ethnicity, gender, and age. Psychooncology 15:248–58, 2006.CrossRefGoogle Scholar
Tasmuth, T, Kataja, M, Blomqvist, C, et al. Treatment-related factors predisposing to chronic pain in patients with breast cancer – a multivariate approach. Acta Oncol 36:625–30, 1997.CrossRefGoogle ScholarPubMed
Tasmuth, T, Blomqvist, C, Kalso, E. Chronic post-treatment symptoms in patients with breast cancer operated in different surgical units. Eur J Surg Oncol 25:38–43, 1999.CrossRefGoogle ScholarPubMed
Perttunen, K, Tasmuth, T, Kalso, E. Chronic pain after thoracic surgery: a follow-up study. Acta Anaesthesiol Scand 43:563–7, 1999.CrossRefGoogle ScholarPubMed
Karmakar, MK, Ho, AM. Postthoracotomy pain syndrome. Thorac Surg Clin 14:345–52, 2004.CrossRefGoogle ScholarPubMed
Gotoda, Y, Kambara, N, Sakai, T. The morbidity, time course and predictive factors for persistent post-thoracotomy pain. Eur J Pain 5:89–96, 2001.CrossRefGoogle ScholarPubMed
Rauch, P, Miny, J, Conroy, T, et al. Quality of life among disease-free survivors of rectal cancer. J Clin Oncol 22:354–60, 2004.CrossRefGoogle ScholarPubMed
Marchettini, P, Formaglio, F, Lacerenza, M. Iatrogenic painful neuropathic complications of surgery in cancer. Acta Anaesthesiol Scand 45:1090–4, 2001.CrossRefGoogle Scholar
Perkins, FM, Kehlet, H. Chronic pain as an outcome of surgery. a review of predictive factors. Anesthesiology 93:1123–33, 2000.CrossRefGoogle ScholarPubMed
Polomano, RC, Bennett, GJ. Chemotherapy-evoked painful peripheral neuropathy. Pain Med 2:8–14, 2001.CrossRefGoogle ScholarPubMed
Quasthoff, S, Hartung, HP. Chemotherapy-induced peripheral neuropathy. J Neurol 249:9–17, 2002.CrossRefGoogle ScholarPubMed
Dropcho, EJ. Neurotoxicity of cancer chemotherapy. Semin Neurol 24:419–26, 2004.CrossRefGoogle ScholarPubMed
Azinovic, I, Calvo, FA, Puebla, F, et al. Long-term normal tissue effects of intraoperative electron radiation therapy (IOERT): late sequelae, tumor recurrence, and second malignancies. Int J Radiat Oncol Biol Phys 49:597–604, 2001.CrossRefGoogle ScholarPubMed
Rubin, DI, Schomberg, PJ, Shepherd, RF, Panneton, JM. Arteritis and brachial plexus neuropathy as delayed complications of radiation therapy. Mayo Clin Proc 76:849–52, 2001.CrossRefGoogle ScholarPubMed
Schierle, C, Winograd, JM. Radiation-induced brachial plexopathy: review. Complication without a cure. J Reconstr Microsurg 20:149–52, 2004.Google Scholar
Vargas, C, Martinez, A, Kestin, LL, et al. Dose-volume analysis of predictors for chronic rectal toxicity after treatment of prostate cancer with adaptive image-guided radiotherapy. Int J Radiat Oncol Biol Phys 62:1297–308, 2005.CrossRefGoogle ScholarPubMed
Wilson, SA, Rex, DK. Endoscopic treatment of chronic radiation proctopathy. Curr Opin Gastroenterol 22:536–40, 2006.CrossRefGoogle ScholarPubMed
Sandel, HD, Davison, SP. Microsurgical reconstruction for radiation necrosis: an evolving disease. J Reconstr Microsurg 23:225–30, 2007.CrossRefGoogle Scholar
Hoff, AO, Gagel, RF. Osteoporosis in breast and prostate cancer survivors. Oncology (Williston Park) 19:651–8, 2005.Google ScholarPubMed
Karimova, EJ, Rai, SN, Howard, SC, et al. Femoral head osteonecrosis in pediatric and young adult patients with leukemia or lymphoma. J Clin Oncol 20:25;1525–31, 2007.CrossRefGoogle Scholar
Merskey, H, Bogduk, N, eds. International Association for the Study of Pain. Task Force on Taxonomy. Classification of chronic pain: descriptions of chronic pain syndromes and definitions of pain terms, 2nd ed. Seattle: IASP Press, 1994.Google Scholar
Lyne, ME, Coyne, PJ, Watson, AC. Pain management issues for cancer survivors. Cancer Pract 10(Suppl 1):S27–32, 2002.CrossRefGoogle ScholarPubMed
Portenoy, RK, Conn, M. Cancer pain syndromes. In: Cancer pain: assessment and management. New York: Cambridge University Press, 2003, pp 89–110.CrossRefGoogle Scholar
Wilgen, CP, Dijkstra, PU, Laan, BF, et al. Morbidity of the neck after head and neck cancer therapy. Head Neck 26:785–91, 2004.CrossRefGoogle ScholarPubMed
Kehlet, H, Jensen, TS, Woolf, CJ. Persistent postsurgical pain: risk factors and prevention. Lancet 367:1618–25, 2006.CrossRefGoogle Scholar
Kline, DG, Hudson, AR. Nerve injuries. Philadelphia: WB Saunders Company, 1995.Google Scholar
Carr, DB, Goudas, LC. Acute pain. Lancet 353:2051–8, 1999.CrossRefGoogle ScholarPubMed
Wilsey, B, Teicheira, D, Caneris, OA, Fishman, SM. A review of sympathetically maintained pain syndromes in the cancer pain population: the spectrum of ambiguous entities of RSD, CRPS, SMP and other pain states related to the sympathetic nervous system. Pain Pract 1:307–23, 2001.CrossRefGoogle ScholarPubMed
McCormack, K, Wake, B, Perez, J, et al. Laparoscopic surgery for inguinal hernia repair: systematic review of effectiveness and economic evaluation. Health Technol Assess 9:1–203, 2005.CrossRefGoogle ScholarPubMed
Fassoulaki, A, Triga, A, Melemeni, A, Sarantopoulos, C. Multimodal analgesia with gabapentin and local anesthetics prevents acute and chronic pain after breast surgery for cancer. Anesth Analg 101:1427–32, 2005.CrossRefGoogle ScholarPubMed
White, PF.Multimodal analgesia: its role in preventing postoperative pain. Curr Opin Investig Drugs 9:76–82, 2008.Google ScholarPubMed
Marhofer, P, Chan, VW. Ultrasound-guided regional anesthesia: current concepts and future trends. Anesth Analg 104:1265–9, 2007.CrossRefGoogle ScholarPubMed
Savage, C, McQuitty, C, Wang, D, Zwischenberger, JB. Postthoracotomy pain management. Chest Surg Clin N Am 12:251–63, 2002.CrossRefGoogle ScholarPubMed
Gendall, KA, Kennedy, RR, Watson, AJ, Frizelle, FA. The effect of epidural analgesia on postoperative outcome after colorectal surgery. Colorectal Dis 9:584–98, 2007.CrossRefGoogle ScholarPubMed
Marret, E, Remy, C, Bonnet, F; Postoperative Pain Forum Group. Meta-analysis of epidural analgesia versus parenteral opioid analgesia after colorectal surgery. Br J Surg 94:665–73, 2007.CrossRefGoogle ScholarPubMed
Elia, N, Lysakowski, C, Tramer, MR. Does multimodal analgesia with acetaminophen, nonsteroidal antiinflammatory drugs, or selective cyclooxygenase-2 inhibitors and patient-controlled analgesia morphine offer advantages over morphine alone? Meta-analyses of randomized trials. Anesthesiology 103:1296–1304, 2005.CrossRefGoogle ScholarPubMed
Straube, S, Derry, S, McQuay, HJ, Moore, RA. Effect of preoperative Cox-II-selective NSAIDs (coxibs) on postoperative outcomes: a systematic review of randomized studies. Acta Anaesthesiol Scand 49:601–13, 2005.CrossRefGoogle ScholarPubMed
Schell, SR. Patient outcomes after axillary lymph node dissection for breast cancer: use of postoperative continuous local anesthesia infusion. J Surg Res 134:124–32, 2006.CrossRefGoogle ScholarPubMed
Beaussier, M, El'Ayoubi, H, Schiffer, E, et al. Continuous preperitoneal infusion of ropivacaine provides effective analgesia and accelerates recovery after colorectal surgery: a randomized, double-blind, placebo-controlled study. Anesthesiology 107:461–8, 2007.CrossRefGoogle ScholarPubMed
Liu, SS, Richman, JM, Thirlby, RC, Wu, CL. Efficacy of continuous wound catheters delivering local anesthetic for postoperative analgesia: a quantitative and qualitative systematic review of randomized controlled trials. J Am Coll Surg 203:914–32, 2006.CrossRefGoogle ScholarPubMed
Tiippana, EM, Hamunen, K, Kontinen, VK, Kalso, E. Do surgical patients benefit from perioperative gabapentin/pregabalin? A systematic review of efficacy and safety. Anesth Analg 104:1545–56, 2007.CrossRefGoogle ScholarPubMed
Ho, KY, Gan, TJ, Habib, AS. Gabapentin and postoperative pain – a systematic review of randomized controlled trials. Pain 126(1–3):91–101, 2006.CrossRefGoogle ScholarPubMed
Ververs, JM, Roumen, RM, Vingerhoets, AJ, et al. Risk, severity and predictors of physical and psychological morbidity after axillary lymph node dissection for breast cancer. Eur J Cancer 37:991–9, 2001.CrossRefGoogle ScholarPubMed
Carpenter, JS, Sloan, P, Andrykowski, MA, et al. Risk factors for pain after mastectomy/lumpectomy. Cancer Pract 7:66–70, 1999.CrossRefGoogle ScholarPubMed
Carpenter, JS, Andrykowski, MA, Sloan, P, et al. Postmastectomy/postlumpectomy pain in breast cancer survivors. J Clin Epidemiol 51:1285–92, 1998.CrossRefGoogle ScholarPubMed
Bosompra, K, Ashikaga, T, O'Brien, PJ, et al. Swelling, numbness, pain, and their relationship to arm function among breast cancer survivors: a disablement process model perspective. Breast J 8:338–48, 2002.CrossRefGoogle ScholarPubMed
Stevens, PE, Dibble, SL, Miaskowski, C. Prevalence, characteristics, and impact of postmastectomy pain syndrome: an investigation of women's experiences. Pain 61:61–8, 1995.CrossRefGoogle ScholarPubMed
Macdonald, L, Bruce, J, Scott, NW, et al. Long-term follow-up of breast cancer survivors with post-mastectomy pain syndrome. Br J Cancer 92:225–30, 2005.CrossRefGoogle ScholarPubMed
Miguel, R, Kuhn, AM, Shons, AR, et al. The effect of sentinel node selective axillary lymphadenectomy on the incidence of postmastectomy pain syndrome. Cancer Control 8:427–30, 2001.CrossRefGoogle ScholarPubMed
Eversley, R, Estrin, D, Dibble, S, et al. Post-treatment symptoms among ethnic minority breast cancer survivors. Oncol Nurs Forum 32:250–6, 2005.CrossRefGoogle ScholarPubMed
Hurley, RW, Cohen, SP, Williams, KA, et al. The analgesic effects of perioperative gabapentin on postoperative pain: a meta-analysis. Reg Anesth Pain Med 31:237–47, 2006.Google ScholarPubMed
Eisenberg, E, Pud, D, Koltun, L, Loven, D. Effect of early administration of the N-methyl-d-aspartate receptor antagonist amantadine on the development of postmastectomy pain syndrome: a prospective pilot study. J Pain 8:223–9, 2007.CrossRefGoogle ScholarPubMed
Hautkappe, M, Roizen, MF, Toledano, A, et al. Review of the effectiveness of capsaicin for painful cutaneous disorders and neural dysfunction. Clin J Pain 14:97–106, 1998.CrossRefGoogle ScholarPubMed
Dajczman, E, Gordon, A, Kreisman, H, Wolkove, N. Long-term postthoracotomy pain. Chest 99:270–4, 1991.CrossRefGoogle ScholarPubMed
Erdek, MA, Staats, PS. Chronic pain and thoracic surgery. Thorac Surg Clin 15:123–30, 2005.CrossRefGoogle ScholarPubMed
Gotoda, Y, Kambara, N, Sakai, T, et al. The morbidity, time course and predictive factors for persistent post-thoracotomy pain. Eur J Pain 5:89–96, 2001.CrossRefGoogle ScholarPubMed
Senturk, M, Ozcan, PE, Talu, GK, et al. The effects of three different analgesia techniques on long-term postthoracotomy pain. Anesth Analg 94:11–15, 2002.CrossRefGoogle ScholarPubMed
Pourel, N, Peiffert, D, Lartigau, E, et al. Quality of life in long-term survivors of oropharynx carcinoma. Int J Radiat Oncol Biol Phys 54:742–51, 2002.CrossRefGoogle ScholarPubMed
Remmler, D, Byers, R, Scheetz, J, et al. A prospective study of shoulder disability resulting from radical and modified neck dissections. Head Neck Surg 8:280–6, 1986.CrossRefGoogle ScholarPubMed
Chua, KS, Reddy, SK, Lee, MC, Patt, RB. Pain and loss of function in head and neck cancer survivors. J Pain Symptom Manage 18:193–202, 1999.CrossRefGoogle ScholarPubMed
Vecht, CJ, Hoff, AM, Kansen, PJ, et al. Types and causes of pain in cancer of the head and neck. Cancer 70:178–84, 1992.3.0.CO;2-E>CrossRefGoogle ScholarPubMed
Grond, S, Zech, D, Lynch, J, et al. Validation of World Health Organization guidelines for pain relief in head and neck cancer: a prospective study. Ann Otol Rhinol Laryngol 102:342–8, 1993.CrossRefGoogle ScholarPubMed
Talmi, YP, Horowitz, Z, Pfeffer, MR, et al. Pain in the neck after neck dissection. Otolaryngol Head Neck Surg 123:302–6, 2000.CrossRefGoogle ScholarPubMed
Wittekindt, C, Liu, WC, Preuss, SF, Guntinas-Lichius, O. Botulinum toxin A for neuropathic pain after neck dissection: a dose-finding study. Laryngoscope 116:1168–71, 2006.CrossRefGoogle ScholarPubMed
Courneya, KS, Seikaly, H, Jha, N, et al. A pilot study of a randomized controlled trial to evaluate the effects of progressive resistance exercise training on shoulder dysfunction caused by spinal accessory neurapraxia/neurectomy in head and neck cancer survivors. Head Neck 26:518–30, 2004.Google Scholar
Flor, H. Phantom-limb pain: characteristics, causes, and treatment. Lancet Neurol 1:182–9, 2002.CrossRefGoogle ScholarPubMed
Elzinga, A, Schans, CP. Phantom pain and phantom sensations in upper limb amputees: an epidemiological study. Pain 87:33–41, 2000.Google Scholar
Jensen, TS, Nikolajsen, L. Phantom pain and other phenomena after amputation. In: Wall, PD, Melzack, RA, eds. Textbook of pain, 4th ed. Edinburgh: Churchill Livingstone, 1999, pp 799–814.Google Scholar
Burton, AW, Fanciullo, GJ, Beasley, RD, Fisch, MJ. Chronic pain in the cancer survivor: a new frontier. Pain Med 8:189–98, 2007.CrossRefGoogle ScholarPubMed
Ben Abraham, R, Marouani, N, Kollender, Y, et al. Dextromethorphan for phantom pain attenuation in cancer amputees: a double-blind crossover trial involving three patients. Clin J Pain 18:282–5, 2002.CrossRefGoogle ScholarPubMed
Ben, Abraham R, Marouani, N, Weinbroum, AA. Dextromethorphan mitigates phantom pain in cancer amputees. Ann Surg Oncol 10:268–74, 2003.Google Scholar
Sakorafas, GH, Peros, G, Cataliotti, L, Vlastos, G. Lymphedema following axillary lymph node dissection for breast cancer. Surg Oncol 15:153–65, 2006.CrossRefGoogle ScholarPubMed
Meneses, KD, McNees, MP. Upper extremity lymphedema after treatment for breast cancer: a review of the literature. Ostomy Wound Manage 53:16–29, 2007.Google ScholarPubMed
Beesley, V, Janda, M, Eakin, E, et al. Lymphedema after gynecological cancer treatment: prevalence, correlates, and supportive care needs. Cancer 109:2607–14, 2007.CrossRefGoogle ScholarPubMed
Lockwood-Rayermann, S.Lymphedema in gynecologic cancer survivors: an area for exploration?Cancer Nurs 30:E11–8, 2007.CrossRefGoogle ScholarPubMed
Okeke, AA, Bates, , Gillatt, DA. Lymphoedema in urological cancer. Eur Urol 45:18–25, 2004.CrossRefGoogle ScholarPubMed
Erickson, VS, Pearson, ML, Ganz, PA, et al. Arm edema in breast cancer patients. J Natl Cancer Inst 93:96–111, 2001.CrossRefGoogle ScholarPubMed
Petrek, JA, Senie, RT, Peters, M, Rosen, PP. Lymphedema in a cohort of breast carcinoma survivors 20 years after diagnosis. Cancer 92:1368–77, 2001.3.0.CO;2-9>CrossRefGoogle Scholar
Morrell, RM, Halyard, MY, Schild, SE, et al. Breast cancer-related lymphedema. Mayo Clin Proc 80:1480–4, 2005.CrossRefGoogle ScholarPubMed
Lane, K, Worsley, D, McKenzie, D. Exercise and the lymphatic system: implications for breast-cancer survivors. Sports Med 35:461–71, 2005.CrossRefGoogle ScholarPubMed
Moseley, AL, Carati, CJ, Piller, NB. A systematic review of common conservative therapies for arm lymphoedema secondary to breast cancer treatment. Ann Oncol 18:639–46, 2007.CrossRefGoogle ScholarPubMed
Golshan, M, Smith, B. Prevention and management of arm lymphedema in the patient with breast cancer. J Support Oncol 4:381–6, 2006.Google ScholarPubMed
Bucci, MK, Bevan, A, Roach, M 3rd. Advances in radiation therapy: conventional to 3D, to IMRT, to 4D, and beyond. CA Cancer J Clin 55:117–34, 2005.CrossRefGoogle ScholarPubMed
Gordils-Perez, J, Rawlins-Duell, R, Kelvin, JF. Advances in radiation treatment of patients with breast cancer. Clin J Oncol Nurs 7:629–36, 2003.CrossRefGoogle ScholarPubMed
Johansson, S, Svensson, H, Denekamp, J. Timescale of evolution of late radiation injury after postoperative radiotherapy of breast cancer patients. Int J Radiat Oncol Biol Phys 48:745–50, 2000.CrossRefGoogle ScholarPubMed
McFarlane, VJ, Clein, GP, Cole, J, et al. Cervical neuropathy following mantle radiotherapy. Clin Oncol (R Coll Radiol) 14:468–71, 2002.CrossRefGoogle ScholarPubMed
Becker, M, Schroth, G, Zbaren, P, et al. Long-term changes induced by high-dose irradiation of the head and neck region: imaging findings. Radiographics 17:5–26, 1997.CrossRefGoogle ScholarPubMed
Maddison, P, Southern, P, Johnson, M. Clinical and MRI discordance in a case of delayed radiation myelopathy. J Neurol Neurosurg Psychiatry 69:563–4, 2000.CrossRefGoogle Scholar
Chan, L, Yeo, W, Leung, SF, et al. Delayed radiation myelopathy after concurrent chemoradiation for hypopharyngeal-esophageal carcinoma. Acta Oncol 44:177–9, 2005.CrossRefGoogle ScholarPubMed
Bye, A, Tropé, C, Loge, JH, et al. Health-related quality of life and occurrence of intestinal side effects after pelvic radiotherapy–evaluation of long-term effects of diagnosis and treatment. Acta Oncol 39:173–80, 2000.Google ScholarPubMed
Vanagunas, A.Radiation-induced gastrointestinal disease. Clin Perspect Gastroenterol March/April:69–75, 2001.Google Scholar
Regimbeau, JM, Panis, Y, Gouzi, JL, et al. Operative and long term results after surgery for chronic radiation enteritis. Am J Surg 182:237–42, 2001.CrossRefGoogle ScholarPubMed
Miller, AR, Martenson, JA, Nelson, H, et al. The incidence and clinical consequences of treatment-related bowel injury. Int J Radiat Oncol Biol Phys 43:817–25, 1999.CrossRefGoogle ScholarPubMed
Marshall, GT, Thirlby, RC, Bredfeldt, JE, Hampson, NB. Treatment of gastrointestinal radiation injury with hyperbaric oxygen. Undersea Hyperb Med 34:35–42, 2007.Google ScholarPubMed
Mann, WJ. Surgical management of radiation enteropathy. Surg Clin North Am 71:977–90, 1991.CrossRefGoogle ScholarPubMed
Jain, G, Scolapio, J, Wasserman, E, Floch, MH. Chronic radiation enteritis: a ten-year follow-up. J Clin Gastroenterol 35:214–17, 2002.CrossRefGoogle ScholarPubMed
Ajlouni, M. Radiation-induced proctitis. Curr Treat Options Gastroenterol 2:20–6, 1999.CrossRefGoogle ScholarPubMed
Otchy, DP, Nelson, H. Radiation injuries of the colon and rectum. Surg Clin North Am 73:1017–35, 1993.CrossRefGoogle ScholarPubMed
Wilson, SA, Rex, DK. Endoscopic treatment of chronic radiation proctopathy. Curr Opin Gastroenterol 22:536–40, 2006.CrossRefGoogle ScholarPubMed
Tagkalidis, PP, Tjandra, JJ. Chronic radiation proctitis. ANZ J Surg 71:230–7, 2001.CrossRefGoogle ScholarPubMed
Colwell, JC, Goldberg, M. A review of radiation proctitis in the treatment of prostate cancer. J Wound Ostomy Continence Nurs 27:179–87, 2000.Google ScholarPubMed
Dall'Era, MA, Hampson, NB, Hsi, RA, et al. Hyperbaric oxygen therapy for radiation induced proctopathy in men treated for prostate cancer. J Urol 176:87–90, 2006.CrossRefGoogle ScholarPubMed
Konishi, T, Watanabe, T, Nagawa, H. Formalin application in the treatment of chronic radiation-induced hemorrhagic proctitis induces acute deterioration of mucosal blood flow. Dis Colon Rectum 49:530–1, 2006.CrossRefGoogle ScholarPubMed
Chapuis, P, Dent, O, Bokey, E, et al. The development of a treatment protocol for patients with chronic radiation-induced rectal bleeding. Aust N Z J Surg 66:680–5, 1996.CrossRefGoogle ScholarPubMed
Tjandra, JJ, Sengupta, S. Argon plasma coagulation is an effective treatment for refractory hemorrhagic radiation proctitis. Dis Colon Rectum 44:1759–65, 2001.CrossRefGoogle ScholarPubMed
Bartleson, JD, Krecke, KN, O'Neill, BP, Brown, PD. Reversible, strokelike migraine attacks in patients with previous radiation therapy. Neuro Oncol 5:121–7, 2003.CrossRefGoogle ScholarPubMed
Pruitt, A, Dalmau, J, Detre, J, et al. Episodic neurologic dysfunction with migraine and reversible imaging findings after radiation. Neurology 67:676–8, 2006.CrossRefGoogle ScholarPubMed
Cordato, DJ, Brimage, P, Masters, LT, Butler, P. Post-cranial irradiation syndrome with migraine-like headaches, prolonged and reversible neurological deficits and seizures. J Clin Neurosci 13:586–90, 2006.CrossRefGoogle ScholarPubMed
Partap, S, Walker, M, Longstreth, WT Jr, Spence, AM. Prolonged but reversible migraine-like episodes long after cranial irradiation. Neurology 66:1105–7, 2006.CrossRefGoogle ScholarPubMed
Aley, KO, et al. Vincristine hyperalgesia in the rat: a model of painful vincristine neuropathy in humans. Neuroscience 73:259–65, 1996.CrossRefGoogle ScholarPubMed
Boyle, FM, et al. Amelioration of experimental cisplatin and paclitaxel neuropathy with glutamate. J Neurooncol 41:107–16, 1999.CrossRefGoogle ScholarPubMed
Polomano, RC, et al. A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel. Pain 94:293–304, 2001.CrossRefGoogle ScholarPubMed
Dougherty, PM, Cata, JP, Cordella, JV, e al. Taxol-induced sensory disturbance is characterized by preferential impairment of myelinated fiber function in cancer patients. Pain 109:132–42, 2004.CrossRefGoogle ScholarPubMed
Koros, C, Papalexi, E, Anastasopoulos, D, et al. Effects of AraC treatment on motor coordination and cerebellar cytoarchitecture in the adult rat. A possible protective role of NAC. Neurotoxicology 28:83–92, 2007.CrossRefGoogle Scholar
Visovsky, C. Chemotherapy-induced peripheral neuropathy. Cancer Invest 21:439–51, 2003.CrossRefGoogle ScholarPubMed
Kannarkat, G, Lasher, EE, Schiff, D. Neurologic complications of chemotherapy agents. Curr Opin Neurol 20:719–25, 2007.Google ScholarPubMed
Verstappen, CC, Heimans, JJ, Hoekman, K, Postma, TJ. Neurotoxic complications of chemotherapy in patients with cancer: clinical signs and optimal management. Drugs 63:1549–63, 2003.CrossRefGoogle ScholarPubMed
Argyriou, AA, Polychronopoulos, P, Koutras, A, et al. Is advanced age associated with increased incidence and severity of chemotherapy-induced peripheral neuropathy?Support Care Cancer 14:223–9, 2006.CrossRefGoogle ScholarPubMed
Quasthoff, S, Hartung, HP. Chemotherapy-induced peripheral neuropathy. J Neurol 249:9–17, 2002.CrossRefGoogle ScholarPubMed
LoMonaco, M, Milone, M, Batocchi, AP, et al. Cisplatin neuropathy: clinical course and neurophysiological findings. J Neurol 239:199–204, 1992.CrossRefGoogle ScholarPubMed
Strumberg, D, Brügge, S, Korn, MW, et al. Evaluation of long-term toxicity in patients after cisplatin-based chemotherapy for non-seminomatous testicular cancer. Ann Oncol 13:229–36, 2002.CrossRefGoogle ScholarPubMed
Fossa, SD. Long-term sequelae after cancer therapy – survivorship after treatment for testicular cancer. Acta Oncol 43:134–41, 2004.Google ScholarPubMed
Oldenburg, J, Fosså, SD, Dahl, AA. Scale for chemotherapy-induced long-term neurotoxicity (SCIN): psychometrics, validation, and findings in a large sample of testicular cancer survivors. Qual Life Res 15:791–800, 2006.CrossRefGoogle Scholar
Moser, EC, Noordijk, EM, Carde, P, et al. Late non-neoplastic events in patients with aggressive non-Hodgkin's lymphoma in four randomized European Organisation for Research and Treatment of Cancer trials. Clin Lymphoma Myeloma 6:122–30, 2005.CrossRefGoogle ScholarPubMed
Oshita, F, Tamura, T, Kojima, A, et al. Late toxicities and complications in three-year survivors of small cell lung cancer. Eur J Cancer 27:427–30, 1991.CrossRefGoogle ScholarPubMed
Benedetti, Panici P, Greggi, S, Scambia, G, et al. Efficacy and toxicity of very high-dose cisplatin in advanced ovarian carcinoma: 4-year survival analysis and neurological follow-up. Int J Gynecol Cancer 3:44–53, 1993.Google Scholar
Cavaletti, G, Zanna, C. Current status and future prospects for the treatment of chemotherapy-induced peripheral neurotoxicity. Eur J Cancer 38:1832–7, 2002.CrossRefGoogle ScholarPubMed
Savarese, DM, Savy, G, Vahdat, L, et al. Prevention of chemotherapy and radiation toxicity with glutamine. Cancer Treat Rev 29:501–13, 2003.CrossRefGoogle ScholarPubMed
Argyriou, AA, Chroni, E, Koutras, A, et al. Vitamin E for prophylaxis against chemotherapy-induced neuropathy: a randomized controlled trial. Neurology 64:26–31, 2005.CrossRefGoogle ScholarPubMed
Cata, JP, Cordella, JV, Burton, AW, et al. Spinal cord stimulation relieves chemotherapy-induced pain: a clinical case report. J Pain Symptom Manage 27:72–8, 2004.CrossRefGoogle ScholarPubMed
Rock, E, DeMichele, A. Nutritional approaches to late toxicities of adjuvant chemotherapy in breast cancer survivors. J Nutr 133(11 Suppl 1):3785S–93S, 2003.CrossRefGoogle ScholarPubMed
Baker, KS, Gurney, JG, Ness, KK, et al. Late effects in survivors of chronic myeloid leukemia treated with hematopoietic cell transplantation: results from the Bone Marrow Transplant Survivor Study. Blood 104:1898–906, 2004.CrossRefGoogle ScholarPubMed
Majhail, NS, Ness, KK, Burns, LJ, et al. Late effects in survivors of Hodgkin and non-Hodgkin lymphoma treated with autologous hematopoietic cell transplantation: a report from the bone marrow transplant survivor study. Biol Blood Marrow Transplant 13:1153–9, 2007.CrossRefGoogle ScholarPubMed
Rugo, HS. Strategies for the prevention of treatment-related bone loss in women receiving adjuvant hormonal therapy. Clin Breast Cancer 7(Suppl 1):S21–8, 2007.CrossRefGoogle ScholarPubMed
Reeves, KW, Faulkner, K, Modugno, F, et al. Study of Osteoporotic Fractures Research Group. Body mass index and mortality among older breast cancer survivors in the Study of Osteoporotic Fractures. Cancer Epidemiol Biomarkers Prev 16:1468–73, 2007.CrossRefGoogle Scholar
Brown, JE, Ellis, SP, Silcocks, P, et al. Effect of chemotherapy on skeletal health in male survivors from testicular cancer and lymphoma. Clin Cancer Res 12:6480–6, 2006.CrossRefGoogle ScholarPubMed
Chen, AC, Petrylak, DP. Complications of androgen-deprivation therapy in men with prostate cancer. Curr Urol Rep 6:210–16, 2005.CrossRefGoogle ScholarPubMed
Limburg, CE. Screening, prevention, detection, and treatment of cancer therapy-induced bone loss in patients with breast cancer. Oncol Nurs Forum 34:55–63, 2007.CrossRefGoogle ScholarPubMed
Molina, JR, Barton, DL, Loprinzi, CL. Chemotherapy-induced ovarian failure: manifestations and management. Drug Saf 28:401–16, 2005.CrossRefGoogle ScholarPubMed
Schultz, PN, Beck, ML, Stava, C, et al. Health profiles in 5836 long-term cancer survivors. Int J Cancer 104:488–95, 2003.CrossRefGoogle ScholarPubMed
Tauchmanovà, L, Rosa, G, Serio, B, et al. Avascular necrosis in long-term survivors after allogeneic or autologous stem cell transplantation: a single center experience and a review. Cancer 97:2453–61, 2003.CrossRefGoogle ScholarPubMed
Greenspan, SL, Bhattacharya, RK, Sereika, SM, et al. Prevention of bone loss in survivors of breast cancer: a randomized, double-blind, placebo-controlled clinical trial. J Clin Endocrinol Metab 92:131–6, 2007.CrossRefGoogle ScholarPubMed
Theriault, RL, Biermann, JS, Brown, E, et al. NCCN Task Force report: bone health and cancer care. J Natl Compr Canc Netw 4(Suppl 2):S1–20, 2006.Google ScholarPubMed
Johnson, RW, Whitton, TL. Management of herpes zoster (shingles) and postherpetic neuralgia. Expert Opin Pharmacother 5:551–9, 2004.CrossRefGoogle ScholarPubMed
Gordon, DB, Love, G. Pharmacological management of neuropathic pain. Pain Manag Nurs 5(Suppl 1):19–33, 2005.CrossRefGoogle Scholar
Dworkin, RH, O'Connor, AB, Backonja, M, et al. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain 132:237–51, 2007.CrossRefGoogle ScholarPubMed
Almadrones, L, McGuire, DB, Walczak, JR, et al. Psychometric evaluation of two scales assessing functional status and peripheral neuropathy associated with chemotherapy for ovarian cancer: a gynecologic oncology group study. Oncol Nurs Forum 31:615–23, 2004.CrossRefGoogle ScholarPubMed
Visovsky, C, Daly, BJ. Clinical evaluation and patterns of chemotherapy-induced peripheral neuropathy. J Am Acad Nurse Pract 16:353–9, 2004.CrossRefGoogle ScholarPubMed
Gruener, D, Lande, S, eds. Pain control in the primary care setting. Glenview, IL: American Pain Society, 2006.Google Scholar
Armstrong, T, Almadrones, L, Gilbert, MR. Chemotherapy-induced peripheral neuropathy. Oncol Nurs Forum 32:305–11, 2005.CrossRefGoogle ScholarPubMed
Arnstein, P.Chronic neuropathic pain: issues in patient education. Pain Manag Nurs 5(4 Suppl 1):34–41, 2004.CrossRefGoogle ScholarPubMed
Tesauro, GM, Rowland, JH, Lustig, C. Survivorship resources for post-treatment cancer survivors. Cancer Pract 10:277–83, 2002.CrossRefGoogle ScholarPubMed
Polomano, RC, Droog, NM, Purinton, MCP, Cohen, AS. Can social support be found on the World Wide Web?: an evaluation of resources for patients with chronic pain. J Pain Palliat Care Pharmacother 21:49–55, 2007.CrossRefGoogle Scholar
Panchal, SJ, et al. Adult cancer pain. Jenkintown, PA: National Comprehensive Cancer Network, 2005. (Clinical practice guidelines in oncology, v.2.2005). Available at: http://www.nccn.org/professionals/physician_gls/PDF/pain.pdf.Google Scholar
Carr, DB, Goudas, LC, Balk, EM, et al. Evidence report on the treatment of pain in cancer patients. J Natl Cancer Inst Monogr (32):23–31, 2004.CrossRefGoogle Scholar

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