The most common cause of nausea and vomiting (NV) in patients with cancer is chemotherapy. There are several pharmacological and nonpharmacological treatments available to treat NV, and many studies show their safety in human pregnancy. NV is usually multifactorial in etiology, resulting from the disease process itself, drug therapy, and/or radiotherapy, chemotherapy, or surgery. A variety of antiemetics have been used for the treatment of various causes of NV associated with cancer and its treatment. Metoclopramide is a dopamine receptor antagonist, and high doses are given for chemotherapy-induced nausea and vomiting (CINV). Corticosteroids that have been commonly used for CINV are dexamethasone and prednisone. Phenothiazines, such as prochlorperazine, promethazine, and chlorpromazine, are commonly used for low emetic risk and breakthrough CINV. Nonpharmacological treatments that are commonly used to treat nausea and vomiting in pregnancy have also shown to be beneficial when given in addition to the antiemetic regimen of CINV.