Book contents
- Cambridge Textbook Of Neuroscience for Psychiatrists
- Reviews
- Cambridge Textbook of Neuroscience for Psychiatrists
- Copyright page
- Contents
- Contributors
- Introduction
- 1 Cells
- 2 Neurotransmitters and Receptors
- 3 Basic Techniques in Neuroscience
- 4 Neuroanatomy
- 5 Neural Circuits
- 6 Modulators
- 7 Genetics
- 8 Neurodevelopment and Neuroplasticity
- 9 Integrated Neurobiology of Specific Syndromes and Treatments
- 9.1 Autism
- 9.2 Attention Deficit Hyperactivity Disorder
- 9.3 Drug Use, Addiction, Tolerance, Withdrawal and Relapse
- 9.4 Anxiety Disorders
- 9.5 Post-Traumatic Stress Disorder
- 9.6 Obsessive–Compulsive and Related Disorders
- 9.7 Major Depressive Disorder
- 9.8 Bipolar Affective Disorder
- 9.9 Psychosis
- 9.10 Schizophrenia
- 9.11 Borderline Personality Disorder
- 9.12 Self-Harm and Suicidality
- 9.13 Medically Unexplained Symptoms
- 9.14 Delirium
- 9.15 Perinatal Disorders
- 9.16 Sleep Disorders
- 9.17 Eating Disorders
- 9.18 Epilepsy and Seizures
- 9.19 Electroconvulsive Therapy
- 9.20 Brain Stimulation
- 10 Neurodegeneration
- Index
- References
9.12 - Self-Harm and Suicidality
from 9 - Integrated Neurobiology of Specific Syndromes and Treatments
Published online by Cambridge University Press: 08 November 2023
Book contents
- Cambridge Textbook Of Neuroscience for Psychiatrists
- Reviews
- Cambridge Textbook of Neuroscience for Psychiatrists
- Copyright page
- Contents
- Contributors
- Introduction
- 1 Cells
- 2 Neurotransmitters and Receptors
- 3 Basic Techniques in Neuroscience
- 4 Neuroanatomy
- 5 Neural Circuits
- 6 Modulators
- 7 Genetics
- 8 Neurodevelopment and Neuroplasticity
- 9 Integrated Neurobiology of Specific Syndromes and Treatments
- 9.1 Autism
- 9.2 Attention Deficit Hyperactivity Disorder
- 9.3 Drug Use, Addiction, Tolerance, Withdrawal and Relapse
- 9.4 Anxiety Disorders
- 9.5 Post-Traumatic Stress Disorder
- 9.6 Obsessive–Compulsive and Related Disorders
- 9.7 Major Depressive Disorder
- 9.8 Bipolar Affective Disorder
- 9.9 Psychosis
- 9.10 Schizophrenia
- 9.11 Borderline Personality Disorder
- 9.12 Self-Harm and Suicidality
- 9.13 Medically Unexplained Symptoms
- 9.14 Delirium
- 9.15 Perinatal Disorders
- 9.16 Sleep Disorders
- 9.17 Eating Disorders
- 9.18 Epilepsy and Seizures
- 9.19 Electroconvulsive Therapy
- 9.20 Brain Stimulation
- 10 Neurodegeneration
- Index
- References
Summary
Self-harm is common; with a prevalence in adolescents of 17–26% it is an issue of enormous public health importance. In absolute terms, few people with suicidal thoughts go on to attempt suicide, but self-harm is strongly associated with completed suicide [1]. It is important to understand the differences between those with suicidal thoughts only and those who go on to complete suicidal actions – this will help us to identify higher-risk individuals and to design effective interventions to reduce suicide attempts. Some clinical (e.g. cannabis use) and environmental (e.g. exposure to self-harm in others) variables have been shown to be associated with transition from suicidal thoughts to attempts [2] but predictive power is low. It is possible that biological markers will have stronger predictive power so it is important to understand the biological basis of self-harm so we can know which putative prognostic markers to test. Understanding the biology of suicidal thoughts will help us to design treatments that reduce these.
- Type
- Chapter
- Information
- Cambridge Textbook of Neuroscience for Psychiatrists , pp. 484 - 489Publisher: Cambridge University PressPrint publication year: 2023
References
Hawton, K, Saunders, KE, O’Connor, RC. Self-harm and suicide in adolescents. Lancet 2012; 379(9834): 2373–2382.CrossRefGoogle ScholarPubMed
Mars, B, Heron, J, Klonsky, ED et al. Predictors of future suicide attempt among adolescents with suicidal thoughts or non-suicidal self-harm: a population-based birth cohort study. Lancet Psychiatry 2019; 6(4): 327–337.CrossRefGoogle ScholarPubMed
O’Connor, RC, Kirtley, OJ. The integrated motivational–volitional model of suicidal behaviour. Philos Trans R Soc London B 2018; 373: 1754.Google ScholarPubMed
Ougrin D, Tranah T, Stahl D, Moran P, Asarnow JR. Therapeutic interventions for suicide attempts and self-harm in adolescents: systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatry 2015 Feb; 54(2): 97–107.e2.Google Scholar
Wilkinson, PO, Qiu, T, Neufeld, S, Jones, PB, Goodyer, IM. Sporadic and recurrent non-suicidal self-injury before age 14 and incident onset of psychiatric disorders by 17 years: prospective cohort study. Br J Psychiatry 2018; 212(4): 222–226.CrossRefGoogle ScholarPubMed
Schmaal, L, van Harmelen, AL, Chatzi, V et al. Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies. Mol Psychiatry 2020; 25(2): 408–427.CrossRefGoogle ScholarPubMed
Tonelli, LH, Stiller, J, Rujescu, D et al. Elevated cytokine expression in the orbitofrontal cortex of victims of suicide. Acta Psychiatr Scand 2008; 117(3): 198–206.CrossRefGoogle Scholar
Minzenberg, MJ, Lesh, TA, Niendam, TA et al. Control-related frontal-striatal function is associated with past suicidal ideation and behavior in patients with recent-onset psychotic major mood disorders. J Affect Disord 2015; 188: 202–209.CrossRefGoogle ScholarPubMed
Liu, RT, Trout, ZM, Hernandez, EM, Cheek, SM, Gerlus, N. A behavioral and cognitive neuroscience perspective on impulsivity, suicide, and non-suicidal self-injury: meta-analysis and recommendations for future research. Neurosci Biobehav Rev 2017; 83: 440–450.CrossRefGoogle ScholarPubMed
Malhi, GS, Das, P, Outhred, T et al. Understanding suicide: focusing on its mechanisms through a lithium lens. J Affect Disord 2018; 241: 338–347.CrossRefGoogle ScholarPubMed
Groschwitz, RC, Plener, PL. The neurobiology of non-suicidal self-injury (NSSI): a review. Suicidol Online 2012; 3: 24–32.Google Scholar
Ballard, ED, Yarrington, JS, Farmer, CA et al. Characterizing the course of suicidal ideation response to ketamine. J Affect Disord 2018; 241: 86–93.CrossRefGoogle Scholar
Croarkin, PE, Nakonezny, PA, Deng, Z-D et al. High-frequency repetitive TMS for suicidal ideation in adolescents with depression. J Affect Disord 2018; 239: 282–290.CrossRefGoogle ScholarPubMed
Maciejewski, DF, Creemers, HE, Lynskey, MT et al. Overlapping genetic and environmental influences on nonsuicidal self-injury and suicidal ideation: different outcomes, same etiology? JAMA Psychiatry 2014; 71(6): 699–705.CrossRefGoogle ScholarPubMed
Lippard, ETC, Johnston, JAY, Spencer, L et al. Preliminary examination of gray and white matter structure and longitudinal structural changes in frontal systems associated with future suicide attempts in adolescents and young adults with mood disorders. J Affect Disord 2019; 245: 1139–1148.CrossRefGoogle Scholar
Van Harmelen, A-L, Schmaal, L, Blumberg, HP. Journal of Affective Disorders Special Issue on Suicide-Related Research: hopeful progress but much research urgently needed. J Affect Disord 2019; 251: 39–41.CrossRefGoogle ScholarPubMed