Book contents
- Cambridge Textbook Of Neuroscience for Psychiatrists
- Reviews
- Cambridge Textbook of Neuroscience for Psychiatrists
- Copyright page
- Contents
- Contributors
- Introduction
- 1 Cells
- 2 Neurotransmitters and Receptors
- 3 Basic Techniques in Neuroscience
- 4 Neuroanatomy
- 5 Neural Circuits
- 6 Modulators
- 7 Genetics
- 8 Neurodevelopment and Neuroplasticity
- 9 Integrated Neurobiology of Specific Syndromes and Treatments
- 10 Neurodegeneration
- Index
- References
2 - Neurotransmitters and Receptors
Published online by Cambridge University Press: 08 November 2023
Book contents
- Cambridge Textbook Of Neuroscience for Psychiatrists
- Reviews
- Cambridge Textbook of Neuroscience for Psychiatrists
- Copyright page
- Contents
- Contributors
- Introduction
- 1 Cells
- 2 Neurotransmitters and Receptors
- 3 Basic Techniques in Neuroscience
- 4 Neuroanatomy
- 5 Neural Circuits
- 6 Modulators
- 7 Genetics
- 8 Neurodevelopment and Neuroplasticity
- 9 Integrated Neurobiology of Specific Syndromes and Treatments
- 10 Neurodegeneration
- Index
- References
Summary
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- Chapter
- Information
- Cambridge Textbook of Neuroscience for Psychiatrists , pp. 16 - 53Publisher: Cambridge University PressPrint publication year: 2023
References
References
Kandel, ER, Schwartz, JH, Jessell, TM, Siegelbaum, SA, Hudspeth, AJ. Principles of Neural Science, 5th ed. McGraw-Hill, Health Professions Division, 2013.Google Scholar
Katzung, BG, Masters, SB, Trevor, AJ. Basic and Clinical Pharmacology, 12th ed. McGraw Hill Medical, 2012.Google Scholar
Hariri, AR, Mattay, VS, Tessitore, A et al. Serotonin transporter genetic variation and the response of the human amygdala. Science 2002; 297(5580): 400–403.CrossRefGoogle ScholarPubMed
Lesch, K-P, Bengel, D, Heils, A et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274(5292): 1527–1531.CrossRefGoogle ScholarPubMed
Caspi, A, Sugden, K, Moffitt, TE et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003; 301(5631): 386–389.CrossRefGoogle ScholarPubMed
Howes, OD, Kapur, S. The dopamine hypothesis of schizophrenia: version III – the final common pathway. Schizophr Bull 2009; 35(3): 549–562.CrossRefGoogle ScholarPubMed
References
Corder, G, Castro, DC, Bruchas, MR, Scherrer, G. Endogenous and exogenous opioids in pain. Annu Rev Neurosci. 2018;41:453–473. doi: 10.1146/annurev-neuro-080317-061522. Epub 2018 May 31. PMID: 29852083CrossRefGoogle ScholarPubMed
Koob, GF, Volkow, ND. Neurobiology of addiction: a neurocircuitry analysis. Lancet Psychiatry. 2016;3(8):760–773. doi: 10.1016/S2215-0366(16)00104-8. PMID: 27475769CrossRefGoogle ScholarPubMed
Heisler, LK, Lam, DD. An appetite for life: brain regulation of hunger and satiety. Curr Opin Pharmacol. 2017;37:100–106. doi: 10.1016/j.coph.2017.09.002. Epub 2017 Nov 5. PMID: 29107871CrossRefGoogle ScholarPubMed
Han, Y, Yuan, K, Zheng, Y, Lu, L. Orexin receptor antagonists as emerging treatments for psychiatric disorders. Neurosci Bull. 2019 Nov 28. doi: 10.1007/s12264-019-00447-9. PMID: 31782044CrossRefGoogle Scholar
Horta, M, Kaylor, K, Feifel, D, Ebner, NC. Chronic oxytocin administration as a tool for investigation and treatment: a cross-disciplinary systematic review. Neurosci Biobehav Rev. 2019;108:1–23. doi: 10.1016/j.neubiorev.2019.10.012. PMID: 31647964CrossRefGoogle ScholarPubMed
Hauser, AS, Chavali, S, Masuho, I et al. Pharmacogenomics of GPCR drug targets. Cell. 2018;172:41–54.e19.CrossRefGoogle ScholarPubMed
References
Howard, DM, Adams, MJ, Clarke, T-K et al. Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions. Nat Neurosci. 2019;22:343–352.CrossRefGoogle ScholarPubMed
Wray, NR, Ripke, S, Mattheisen, M et al. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet. 2018; 50:668–681.CrossRefGoogle ScholarPubMed
Ripke, S, Neale, BM, Corvin, A et al. Biological insights from 108 schizophrenia-associated genetic loci. Nature. 2014;511:421–427.Google Scholar
Trubetskoy, V, Pardiñas, AF, Qi, T et al. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature. 2022;604(7906):502–508.CrossRefGoogle ScholarPubMed
Mullins, N, Forstner, AJ, O’Connell, KS, Coombes, B, Coleman, JRI, Qiao, Z et al. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nat Genet. 2021;53(6):817–829.CrossRefGoogle Scholar
Consortium TN and PAS of the PG, O’Dushlaine, C, Rossin, L et al. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nat Neurosci. 2015;18:199–209.Google Scholar
Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet. 2013;381:1371–1379.CrossRefGoogle Scholar
Craddock, N, Sklar, P. Genetics of bipolar disorder. Lancet. 2013;381:1654–1662.CrossRefGoogle ScholarPubMed
Power, RA, Tansey, KE, Buttenschøn, HN et al. Genome-wide association for major depression through age at onset stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Biol Psychiatry. 2017;81:325–335.CrossRefGoogle Scholar
Howes, O, McCutcheon, R, Stone, J. Glutamate and dopamine in schizophrenia: an update for the 21st century. J Psychopharmacol. 2015;29:97–115.CrossRefGoogle Scholar
Laruelle, M, Kegels, M, Kegeles, LS, Abi-Dargham, A. Glutamate, dopamine, and schizophrenia. Ann N Y Acad Sci. 2003;1003:138–158.CrossRefGoogle ScholarPubMed
Kesby, J, Eyles, D, McGrath, J, Scott, J. Dopamine, psychosis and schizophrenia: the widening gap between basic and clinical neuroscience. Transl Psychiatry. 2018;8:30.CrossRefGoogle ScholarPubMed
Sekar, A, Bialas, AR, de Rivera, H et al. Schizophrenia risk from complex variation of complement component 4. Nature. 2016;530:177–183.CrossRefGoogle ScholarPubMed
Owens, MJ, Nemeroff, CB. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin Chem. 1994;40:288–295.CrossRefGoogle ScholarPubMed
Stahl, SM. Mechanism of action of serotonin selective reuptake inhibitors: serotonin receptors and pathways mediate therapeutic effects and side effects. J Affect Disord. 1998;51:215–235.CrossRefGoogle ScholarPubMed
Faraone, SV, Larsson, H. Genetics of attention deficit hyperactivity disorder. Mol Psychiatry. 2019;24:562–575.CrossRefGoogle ScholarPubMed
Thapar, A, Martin, J, Mick, E et al. Psychiatric gene discoveries shape evidence on ADHD’s biology. Mol Psychiatry. 2016;21:1202–1207.CrossRefGoogle ScholarPubMed
Demontis, D, Walters, RK, Martin, J et al. Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nat Genet. 2019;51:63–75.CrossRefGoogle ScholarPubMed
Autism Spectrum Disorders Working Group of the Psychiatric Genomics Consortium, Consortium TASDWG of TPG. Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. Mol Autism. 2017;8:21.CrossRefGoogle Scholar
Further Reading
Abdulrahim, D, Bowden-Jones, O, on behalf of the NEPTUNE Expert Group. Guidance on the Management of Acute and Chronic Harms of Club Drugs and Novel Psychoactive Substances. Novel Psychoactive Treatment UK Network (NEPTUNE), 2015.Google Scholar
Koob, GF, Volkow, ND. Neurobiology of addiction: a neurocircuitry analysis. Lancet Psychiatry 2016; 3(8): 760–773.CrossRefGoogle ScholarPubMed