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9.17 - Eating Disorders

from 9 - Integrated Neurobiology of Specific Syndromes and Treatments

Published online by Cambridge University Press:  08 November 2023

Mary-Ellen Lynall
Affiliation:
University of Cambridge
Peter B. Jones
Affiliation:
University of Cambridge
Stephen M. Stahl
Affiliation:
University of California, San Diego
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Summary

Eating disorders are a group of heterogeneous mental disorders characterised by a distorted relationship to food and eating that often leads to abnormalities in body weight, including both extremes of the weight spectrum. In this section we focus on three disorders: anorexia nervosa, bulimia nervosa and binge eating disorder. Both anorexia nervosa and bulimia nervosa often have an early onset in adolescence or young adulthood and are much more common in females than in males, whereas binge eating disorder is nearly similarly prevalent in men and women (around 5%) and can start later in life [1]. Anorexia nervosa has the highest mortality rate (up to 20%) of any psychiatric disease and a prevalence around 1% in women [1]. Bulimia nervosa has a higher prevalence in women, around 2%, and occurs often undetected for longer periods [1]. Despite the huge impact that eating disorders can have on individuals and families, data on prevalence, frequency of specific symptoms and comorbidities are only sporadically available. The pathophysiology of these diseases is still only partially understood. There is still no specific pharmacological treatment available, which can be partially explained by the multifactorial origin of the diseases and the still insufficiently understood pathophysiology.

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Publisher: Cambridge University Press
Print publication year: 2023

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References

Keski-Rahkonen, A, Mustelin, L. Epidemiology of eating disorders in Europe: prevalence, incidence, comorbidity, course, consequences, and risk factors. Curr Opin Psychiatry 2016; 29(6): 340345.CrossRefGoogle ScholarPubMed
Frank, GKW, Shott, ME, DeGuzman, MC. Recent advances in understanding anorexia nervosa. F1000Res 2019; 8: F1000 Faculty Rev-504.CrossRefGoogle Scholar
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th ed. (DSM-5). American Psychiatric Association, 2013.Google Scholar
Yilmaz, Z, Hardaway, JA, Bulik, CM. Genetics and epigenetics of eating disorders. Adv Genomics Genet 2015; 5: 131150.Google ScholarPubMed
Watson, HJ, Yilmaz, Z, Thornton, LM et al. Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nat Genet 2019; 51(8): 12071214.CrossRefGoogle ScholarPubMed
Brockmeyer, T, Friederich, HC, Schmidt, U. Advances in the treatment of anorexia nervosa: a review of established and emerging interventions. Psychol Med 2018; 48(8): 12281256.CrossRefGoogle ScholarPubMed
Schalla, MA, Stengel, A. Activity based anorexia as an animal model for anorexia nervosa: a systematic review. Front Nutr 2019; 6: 69.CrossRefGoogle ScholarPubMed
Scharner, S, Prinz, P, Goebel-Stengel, M et al. Activity-based anorexia reduces body weight without inducing a separate food intake microstructure or activity phenotype in female rats mediation via an activation of distinct brain nuclei. Front Neurosci 2016; 10: 475.CrossRefGoogle ScholarPubMed
Misra, M, Klibanski, A. Endocrine consequences of anorexia nervosa. Lancet Diabetes Endocrinol 2014; 2(7): 581592.CrossRefGoogle ScholarPubMed
Bernardoni, F, King, JA, Geisler, D et al. Weight restoration therapy rapidly reverses cortical thinning in anorexia nervosa: a longitudinal study. Neuroimage 2016; 130: 214222.CrossRefGoogle ScholarPubMed
Frintrop, L, Liesbrock, J, Paulukat, L et al. Reduced astrocyte density underlying brain volume reduction inactivity-based anorexia rats. World J Biol Psychiatry 2018; 19(3): 225235.CrossRefGoogle ScholarPubMed
Miles, AE, Voineskos, AN, French, L, Kaplan, AS. Subcortical volume and cortical surface architecture in women with acute and remitted anorexia nervosa: an exploratory neuroimaging study. J Psychiatr Res 2018; 102: 179185.CrossRefGoogle ScholarPubMed
Duane Haines, GAM. Fundamental Neuroscience for Basic and Clinical Applications, 5th ed. Elsevier, 2017.Google Scholar
Jiang, T, Soussignan, R, Carrier, E, Royet, JP. Dysfunction of the mesolimbic circuit to food odors in women with anorexia and bulimia nervosa: a fMRI study. Front Hum Neurosci 2019; 13: 117.CrossRefGoogle ScholarPubMed
Monteleone, AM, Castellini, G, Volpe, U et al. Neuroendocrinology and brain imaging of reward in eating disorders: a possible key to the treatment of anorexia nervosa and bulimia nervosa. Prog Neuropsychopharmacol Biol Psychiatry 2018; 80(Pt B): 132142.CrossRefGoogle Scholar
Hinney, A, Friedel, S, Remschmidt, H, Hebebrand, J. Genetic risk factors in eating disorders. Am J Pharmacogenomics 2004; 4(4): 209223.CrossRefGoogle ScholarPubMed
Patel, RS, Olten, B, Patel, P, Shah, K, Mansuri, Z. Hospitalization outcomes and comorbidities of bulimia nervosa: a nationwide inpatient study. Cureus 2018; 10(5): e2583.Google ScholarPubMed
Munn-Chernoff, MA, Johnson, EC, Chou, YL et al. Shared genetic risk between eating disorder- and substance-use-related phenotypes: evidence from genome-wide association studies. Addict Biol 2020; 26(1): e12880.CrossRefGoogle ScholarPubMed
Donnelly, B, Touyz, S, Hay, P et al. Neuroimaging in bulimia nervosa and binge eating disorder: a systematic review. J Eat Disord 2018; 6: 3.CrossRefGoogle ScholarPubMed
Skunde, M, Walther, S, Simon, JJ et al. Neural signature of behavioural inhibition in women with bulimia nervosa. J Psychiatry Neurosci 2016; 41(5): E69E78.CrossRefGoogle ScholarPubMed
Kekic, M, Bartholdy, S, Cheng, J et al. Increased temporal discounting in bulimia nervosa. Int J Eat Disord 2016; 49(12): 10771081.CrossRefGoogle ScholarPubMed
Frank, GK, Shott, ME, Riederer, J, Pryor, TL. Altered structural and effective connectivity in anorexia and bulimia nervosa in circuits that regulate energy and reward homeostasis. Transl Psychiatry 2016; 6(11): e932.CrossRefGoogle ScholarPubMed
Westwater, ML, Seidlitz, J, Diederen, KMJ, Fischer, S, Thompson, JC. Associations between cortical thickness, structural connectivity and severity of dimensional bulimia nervosa symptomatology. Psychiatry Res Neuroimaging 2018; 271: 118125.CrossRefGoogle ScholarPubMed
Coutinho, J, Ramos, AF, Maia, L et al. Volumetric alterations in the nucleus accumbens and caudate nucleus in bulimia nervosa: a structural magnetic resonance imaging study. Int J Eat Disord 2015; 48(2): 206214.CrossRefGoogle ScholarPubMed
Seitz, J, Hueck, M, Dahmen, B et al. Attention network dysfunction in bulimia nervosa: an fMRI study. PLoS One 2016; 11(9): e0161329.CrossRefGoogle ScholarPubMed
Kessler, RM, Hutson, PH, Herman, BK, Potenza, MN. The neurobiological basis of binge-eating disorder. Neurosci Biobehav Rev 2016; 63: 223238.CrossRefGoogle ScholarPubMed

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