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2.4 - Basic Pharmacology of Specific Neurotransmitter Pathways

from 2 - Neurotransmitters and Receptors

Published online by Cambridge University Press:  08 November 2023

By
Emanuele F. Osimo  and
Stephen M. Stahl
Edited by
Mary-Ellen Lynall ,
Peter B. Jones  and
Stephen M. Stahl
Mary-Ellen Lynall
Affiliation:
University of Cambridge
Peter B. Jones
Affiliation:
University of Cambridge
Stephen M. Stahl
Affiliation:
University of California, San Diego
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Summary

Many substances act as transmitters in the central nervous system. We will focus on those small molecules which have been most implicated in neuropsychiatric conditions, namely serotonin, dopamine, gamma-aminobutyric acid (GABA), noradrenaline, acetylcholine and glutamate; for further reading, see [1] and [2].

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Chapter
Information
Cambridge Textbook of Neuroscience for Psychiatrists , pp. 27 - 33
Publisher: Cambridge University Press
Print publication year: 2023

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References

Kandel, ER, Schwartz, JH, Jessell, TM, Siegelbaum, SA, Hudspeth, AJ. Principles of Neural Science, 5th ed. McGraw-Hill, Health Professions Division, 2013.Google Scholar
Katzung, BG, Masters, SB, Trevor, AJ. Basic and Clinical Pharmacology, 12th ed. McGraw Hill Medical, 2012.Google Scholar
Hariri, AR, Mattay, VS, Tessitore, A et al. Serotonin transporter genetic variation and the response of the human amygdala. Science 2002; 297(5580): 400–403.CrossRefGoogle ScholarPubMed
Lesch, K-P, Bengel, D, Heils, A et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274(5292): 1527–1531.CrossRefGoogle ScholarPubMed
Caspi, A, Sugden, K, Moffitt, TE et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003; 301(5631): 386–389.CrossRefGoogle ScholarPubMed
Howes, OD, Kapur, S. The dopamine hypothesis of schizophrenia: version III – the final common pathway. Schizophr Bull 2009; 35(3): 549–562.CrossRefGoogle ScholarPubMed

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