Book contents
- Cambridge Textbook Of Neuroscience for Psychiatrists
- Reviews
- Cambridge Textbook of Neuroscience for Psychiatrists
- Copyright page
- Contents
- Contributors
- Introduction
- 1 Cells
- 2 Neurotransmitters and Receptors
- 3 Basic Techniques in Neuroscience
- 4 Neuroanatomy
- 5 Neural Circuits
- 6 Modulators
- 7 Genetics
- 8 Neurodevelopment and Neuroplasticity
- 9 Integrated Neurobiology of Specific Syndromes and Treatments
- 9.1 Autism
- 9.2 Attention Deficit Hyperactivity Disorder
- 9.3 Drug Use, Addiction, Tolerance, Withdrawal and Relapse
- 9.4 Anxiety Disorders
- 9.5 Post-Traumatic Stress Disorder
- 9.6 Obsessive–Compulsive and Related Disorders
- 9.7 Major Depressive Disorder
- 9.8 Bipolar Affective Disorder
- 9.9 Psychosis
- 9.10 Schizophrenia
- 9.11 Borderline Personality Disorder
- 9.12 Self-Harm and Suicidality
- 9.13 Medically Unexplained Symptoms
- 9.14 Delirium
- 9.15 Perinatal Disorders
- 9.16 Sleep Disorders
- 9.17 Eating Disorders
- 9.18 Epilepsy and Seizures
- 9.19 Electroconvulsive Therapy
- 9.20 Brain Stimulation
- 10 Neurodegeneration
- Index
- References
9.2 - Attention Deficit Hyperactivity Disorder
from 9 - Integrated Neurobiology of Specific Syndromes and Treatments
Published online by Cambridge University Press: 08 November 2023
Book contents
- Cambridge Textbook Of Neuroscience for Psychiatrists
- Reviews
- Cambridge Textbook of Neuroscience for Psychiatrists
- Copyright page
- Contents
- Contributors
- Introduction
- 1 Cells
- 2 Neurotransmitters and Receptors
- 3 Basic Techniques in Neuroscience
- 4 Neuroanatomy
- 5 Neural Circuits
- 6 Modulators
- 7 Genetics
- 8 Neurodevelopment and Neuroplasticity
- 9 Integrated Neurobiology of Specific Syndromes and Treatments
- 9.1 Autism
- 9.2 Attention Deficit Hyperactivity Disorder
- 9.3 Drug Use, Addiction, Tolerance, Withdrawal and Relapse
- 9.4 Anxiety Disorders
- 9.5 Post-Traumatic Stress Disorder
- 9.6 Obsessive–Compulsive and Related Disorders
- 9.7 Major Depressive Disorder
- 9.8 Bipolar Affective Disorder
- 9.9 Psychosis
- 9.10 Schizophrenia
- 9.11 Borderline Personality Disorder
- 9.12 Self-Harm and Suicidality
- 9.13 Medically Unexplained Symptoms
- 9.14 Delirium
- 9.15 Perinatal Disorders
- 9.16 Sleep Disorders
- 9.17 Eating Disorders
- 9.18 Epilepsy and Seizures
- 9.19 Electroconvulsive Therapy
- 9.20 Brain Stimulation
- 10 Neurodegeneration
- Index
- References
Summary
Attention deficit hyperactivity disorder (ADHD) is a childhood-onset disorder with a prevalence of 5%. It is clinically defined by symptoms of inattention, motor hyperactivity and impulsivity. In addition to the core symptoms, it has also been associated with impairment in cognitive domains. ADHD is highly heritable and multifactorial in origin; multiple genes and non-inherited factors contribute to the aetiology of the disorder. ADHD has been associated with slower maturation of long white matter tracts and decreased volume in brain regions relevant for executive function, sustained attention, impulse suppression and regulation of motor activity. In addition to structural brain changes, a range of brain networks and dysregulation of neurotransmitter signalling have also been associated with ADHD. However, no diagnostic neurobiological markers are currently available for clinical use.
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- Information
- Cambridge Textbook of Neuroscience for Psychiatrists , pp. 397 - 402Publisher: Cambridge University PressPrint publication year: 2023
References
Faraone, SV, Asherson, P, Banaschewski, T et al. Attention-deficit/hyperactivity disorder. Nat Rev Dis Prim 2015; 1: 15020.CrossRefGoogle ScholarPubMed
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th ed. (DSM-5). American Psychiatric Association, 2013.Google Scholar
World Health Organization. International Classification of Diseases, 11th ed. (ICD-11). World Health Organization, 2018.Google Scholar
Faraone, SV, Larsson, H. Genetics of attention deficit hyperactivity disorder. Mol Psychiatry 2019; 24: 562–575.CrossRefGoogle ScholarPubMed
Demontis, D, Walters, RK, Athanasiadis, G et al. Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains. Nat Genet 2023; 55: 198–208.CrossRefGoogle ScholarPubMed
Gonon, F. The dopaminergic hypothesis of attention-deficit/hyperactivity disorder needs re-examining. Trends Neurosci 2009; 32: 2–8.CrossRefGoogle ScholarPubMed
Castellanos, FX, Lee, PP, Sharp, W et al. Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder. JAMA 2002; 288: 1740–1748.CrossRefGoogle ScholarPubMed
Durston, S, Hulshoff Pol, HE, Schnack, HG et al. Magnetic resonance imaging of boys with attention-deficit/hyperactivity disorder and their unaffected siblings. J Am Acad Child Adolesc Psychiatry 2004; 43: 332–340.CrossRefGoogle ScholarPubMed
Greven, CU, Bralten, J, Mennes, M et al. Developmentally stable whole-brain volume reductions and developmentally sensitive caudate and putamen volume alterations in those with attention-deficit/hyperactivity disorder and their unaffected siblings. JAMA Psychiatry 2015; 72: 490–499.CrossRefGoogle ScholarPubMed
Stoodley, CJ, Schmahmann, JD. Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies. Neuroimage 2009; 44: 489–501.CrossRefGoogle ScholarPubMed
Frodl, T, Skokauskas, N. Meta-analysis of structural MRI studies in children and adults with attention deficit hyperactivity disorder indicates treatment effects. Acta Psychiatr Scand 2012; 125: 114–126.CrossRefGoogle ScholarPubMed
Shaw, P, Eckstrand, K, Sharp, W et al. Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proc Natl Acad Sci USA 2007; 104: 19649–19654.CrossRefGoogle ScholarPubMed
Hoogman, M, Muetzel, R, Guimaraes, JP et al. Brain imaging of the cortex in ADHD: a coordinated analysis of large-scale clinical and population-based samples. Am J Psychiatry 2019; 176: 531–542.CrossRefGoogle ScholarPubMed
van Ewijk, H, Heslenfeld, DJ, Zwiers, MP, Buitelaar, JK, Oosterlaan, J. Diffusion tensor imaging in attention deficit/hyperactivity disorder: a systematic review and meta-analysis. Neurosci Biobehav Rev 2012; 36: 1093–1106.CrossRefGoogle ScholarPubMed
Hart, H, Radua, J, Nakao, T, Mataix-Cols, D, Rubia, K. Meta-analysis of functional magnetic resonance imaging studies of inhibition and attention in attention-deficit/hyperactivity disorder: exploring task-specific, stimulant medication, and age effects. JAMA Psychiatry 2013; 70: 185–198.CrossRefGoogle ScholarPubMed
Plichta, MM, Scheres, A. Ventral-striatal responsiveness during reward anticipation in ADHD and its relation to trait impulsivity in the healthy population: a meta-analytic review of the fMRI literature. Neurosci Biobehav Rev 2014; 38: 125–134.CrossRefGoogle ScholarPubMed
Cortese, S, Kelly, C, Chabernaud, C et al. Toward systems neuroscience of ADHD: a meta-analysis of 55 fMRI studies. Am J Psychiatry 2012; 169: 1038–1055.CrossRefGoogle ScholarPubMed
Posner, J, Park, C, Wang, Z. Connecting the dots: a review of resting connectivity MRI studies in attention-deficit/hyperactivity disorder. Neuropsychol Rev 2014; 24: 3–15.CrossRefGoogle ScholarPubMed