Here, at the start, I introduce important emphases and divergences within a range of posthuman discourses. Particularly, the distinction between a transhuman empiricism and a reflective, critical posthumanism will be addressed (in this chapter) as a replay of the two-culture noncommunication that C. P. Snow observed (circa 1959) between poets who were deficient in science and scientists who were thought to be “shallowly optimistic, unaware of man’s condition” (Snow, “Two Cultures,” 5). This said, each of the posthumanist listings in the introduction by Latour, Hayles, Wolfe, Barad, Jane Bennett, and Patricia MacCormack offer encouraging signs that cross-disciplinary conversations and articulations are becoming the order of the day in twenty-first-century posthumanist discourse. Our “imbrication” (to again cite Wolfe 2010, xv) of human and nonhuman networking is thrust on us, not a matter of personal choice or subjective preference.