This chapter examines the major rebellions that occurred in Spanish America during the era of North American colonial protest and rebellion against British policies and government. It focuses on the revolt of the city of Quito in 1765, the Andean rebellions started by Tupac Amaru in 1780, and the 1781 Comunero rebellion in New Granada, set in the context of Spanish administrative and fiscal reforms under Charles III and Spanish geopolitical conflict with Britain between the Seven Years’ War and the American War of independence. The principal purpose here is to enquire into the origins of the rebellions, their organization and social composition, and the political attitudes and ideas of their participants. In addition to comparing the Spanish American rebellions in terms of their causes, political cultures and political impacts, it also reflects on their contemporaneous relationship to the American Revolution and their place in the wider challenge to European monarchies during the Age of Revolution.