The chapter examines a classic subject of HRI, social robotics, and the law, such as the design, manufacture, and use of humanoid AI robots for healthcare. The aim is to illustrate a new set of legal challenges that are unique to these systems when displayed in outer space. Such challenges may require the adoption of new legal standards, in particular, either sui generis standards of space law, or stricter or more flexible standards for HRI in space missions, down to a new “principle of equality” between human standards and robotic standards in outer space. The chapter complements current discussions and initiatives on the development of standards for the use of humanoid AI robots in health law, consumer law, and cybersecurity by considering the realignment of terrestrial standards that we may thus expect with the increasing use of humanoid AI systems in space journeys. The assumption is that breathtaking advancements of AI and robotics, current trends on the privatization of the space, and the evolution of current regulatory frameworks, also but not only in space law, will put the development of these new legal standards in the spotlight.