Stigma can maintain discrimination and oppression and reduce compassion and understanding. In the area of mental illness and psychological help seeking, stigma acts as a considerable barrier to recovery and adds additional burdens to be managed. This reality has led many different research groups to explore the workings of stigma and ways to intervene to help people who suffer from the stigma associated with mental health problems. We wanted to create a state-of-the-science source for the best research being done in this area and so we organized the Handbook of Stigma and Mental Health. This chapter provides an overview to the Handbook and the excellent research that is reviewed in it. In their chapters, the authors of the Handbook answer four important questions: “What are the forms of mental health stigma?”; “What are impacts of mental health stigma?”; “How can we develop interventions to reduce mental health stigma across contexts?”; “How can we understand the specific ways that mental health stigma impacts different groups (e.g., racial minorities, veterans)?” We hope that asking these questions will stimulate and drive more innovative research in the future.