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Placebos

from Psychology, health and illness

Published online by Cambridge University Press:  18 December 2014

By
Irving Kirsch
Edited by
Susan Ayers ,
Andrew Baum ,
Chris McManus ,
Stanton Newman ,
Kenneth Wallston ,
John Weinman  and
Robert West
Irving Kirsch
Affiliation:
University of Hull
Susan Ayers
Affiliation:
University of Sussex
Andrew Baum
Affiliation:
University of Pittsburgh
Chris McManus
Affiliation:
St Mary's Hospital Medical School
Stanton Newman
Affiliation:
University College and Middlesex School of Medicine
Kenneth Wallston
Affiliation:
Vanderbilt University School of Nursing
John Weinman
Affiliation:
United Medical and Dental Schools of Guy's and St Thomas's
Robert West
Affiliation:
St George's Hospital Medical School, University of London
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Summary

Overview

A placebo is a sham treatment that may be used clinically to placate a patient or experimentally to establish the efficacy of a drug or other medical procedure. The placebo effect is the effect produced by administering a placebo. In addition, active medications may produce placebo effects as well as drug effects and these may be additive. In this case, the placebo effect is that portion of the treatment effect that was produced psychologically, rather than through physical means.

Typically, placebos are physically inert substances which are identical in appearance to an active drug. Occasionally, active substances are used as placebos. Active placebos have side-effects that mimic those of the drug being investigated, but do not possess the physical properties hypothesized to produce the beneficial treatment effect. Active placebos are used to prevent patients from using the sensory cues provided by side effects to deduce the condition to which they have been randomized.

Placebo effects are not limited to drug treatments. Any medical procedure can have effects due to the physical properties of the treatment and effects due to its psychological properties. Just as the effects of the physical properties of a medication can be tested by comparing its effects to those of a sham medication, so too the physically produced effects of other medical procedures can be established by comparison with sham procedures (e.g. sham surgery).

Type
Chapter
Information
Cambridge Handbook of Psychology, Health and Medicine , pp. 161 - 167
Publisher: Cambridge University Press
Print publication year: 2007

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References

Beecher, H. K. (1955). The powerful placebo. Journal of the American Medical Association, 159(17), 1602–6.Google Scholar
Beecher, H. K. (1961). Surgery as placebo: a quantitative study of bias. Journal of the American Medical Association, 176, 1102–7.Google Scholar
Benedetti, F., Maggi, G., Lopiano, L.et al. (2003). Open versus hidden medical treatments: the patient's knowledge about a therapy affects the therapy outcome. Prevention & Treatment, 6, Article 1. Available on the World Wide Web: http://journals.apa.org/prevention/volume6/pre0060001a.html.
Blackwell, B., Bloomfield, S. S. & Buncher, C. R. (1972). Demonstration to medical students of placebo responses and non-drug factors. The Lancet, 19, 1279–82.Google Scholar
Branthwaite, A. & Cooper, P. (1981). Analgesic effects of branding in treatment of headaches. British Medical Journal (Clin Res Ed), 282(6276), 1576–8.Google Scholar
Brody, H. & Brody, D. (2000). The placebo response: how you can release the body's inner pharmacy for better health. New York: Cliff Street Books/HarperCollins Publishers.
Cobb, L., Thomas, G. I., Dillard, D. H., Merendino, K. A. & Bruce, R. A. (1959). An evaluation of internal-mammary artery ligation by a double blind technique. New England Journal of Medicine, 260, 1115–8.Google Scholar
Craen, A. J. M., Moerman, D. E., Heisterkamp, S. H.et al. (1999). Placebo effect in the treatment of duodenal ulcer. British Journal of Clinical Pharmacology, 48, 853–60.Google Scholar
Craen, A. J. M., Roos, P. J., Vries, A. L. & Kleijnen, J. (1996). Effect of colour of drugs: systematic review of perceived effect of drugs and their effectiveness. British Medical Journal, 313, 1624–6.Google Scholar
Craen, A. J. M., Tijssen, J. G. P., Gans, J. & Kleijnen, J. (2000). Placebo effect in the acute treatment of migraine: subcutaneous placebos are better than oral placebos. Journal of Neurology, 247, 183–8.Google Scholar
Dimond, E. G., Kittle, C. F. & Crockett, J. E. (1960). Comparison of internal mammary ligation and sham operation for angina pectoris. American Journal of Cardiology, 5, 483–6.Google Scholar
Evans, F. J. (1974). The placebo response in pain reduction. Advances in Neurology, 4, 289–96.Google Scholar
Healy, D. (2003). Lines of evidence on the risks of suicide with selective serotonin reuptake inhibitors. Psychotherapy and Psychosomatics, 72(2), 71–9.Google Scholar
Healy, D. & Whitaker, C. (2003). Antidepressants and suicide: risk–benefit conundrums. Journal of Psychiatry and Neuroscience, 28(5), 331–7.Google Scholar
Hollon, S. D., Shelton, R. C. & Loosen, P. T. (1991). Cognitive therapy and pharmacotherapy for depression. Journal of Consulting and Clinical Psychology, 59, 88–99.Google Scholar
Honigfeld, G. (1964a). Non-specific Factors in Treatment. I. Review of Placebo Reactions and Placebo Reactors. Diseases of the Nervous System, 25, 145–56.Google Scholar
Honigfeld, G. (1964b). Non-specific Factors in Treatment. II. Review of Social–Psychological Factors. Diseases of the Nervous System, 25, 225–39.Google Scholar
Hróbjartsson, A. & Gøtzsche, P. C. (2001). An analysis of clinical trials comparing placebo with no treatment. New England Journal of Medicine, 344, 1594–602.Google Scholar
Huskisson, E. (1974). Simple analgesics for arthritis. British Medical Journal, 196–200.Google Scholar
Kantor, T. G., Sunshine, A., Laska, E., Meisner, M. & Hopper, M. (1966). Oral analgesic studies: pentazocine hydrochloride, codeine, aspirin, and placebo and their influence on response to placebo. Clinical Pharmacology and Therapeutics, 7(4), 447–54.Google Scholar
Kirsch, I. (1978). The placebo effect and the cognitive-behavioral revolution. Cognitive Therapy and Research, 2(3), 255–64.Google Scholar
Kirsch, I. (1985). Response Expectancy as a Determinant of Experience and Behavior. American Psychologist, 40(11), 1189–202.Google Scholar
Kirsch, I. (1997). Specifying nonspecifics: psychological mechanisms of placebo effects. In Harrington, A. (Ed.). The placebo effect: an interdisciplinary exploration (pp. 166–86). Cambridge, MA: Harvard University Press.
Kirsch, I. & Council, J.R. (1992). Situational and personality correlates of hypnotic responsiveness. In Nash, M. R. & Fromm, E. (Ed.). Contemporary hypnosis research (pp. 267–91). New York, NY: Guilford Press.
Kirsch, I., Lynn, S. J., Vigorito, M. & Miller, R. R. (2004). The role of cognition in classical and operant conditioning. Journal of Clinical Psychology, 60(4), 369–92.Google Scholar
Kirsch, I., Moore, T. J., Scoboria, A. & Nicholls, S. S. (2002). The emperor's new drugs: an analysis of antidepressant medication data submitted to the U.S. Food and Drug Administration. Prevention and Treatment, 5. Available on the World Wide Web: http://www.journals.apa.org/prevention/volume5/pre0050023a.html.
Kirsch, I. & Sapirstein, G. (1998). Listening to Prozac but hearing placebo: a meta-analysis of antidepressant medication. Prevention and Treatment, 1, Article 0002a, Available on the World Wide Web: http://www.journals.apa.org/prevention/volume1/pre0010002a.html.
Kirsch, I., Scoboria, A. & Moore, T. J. (2002). Antidepressants and placebos: secrets, revelations, and unanswered questions. Prevention and Treatment. Available on the World Wide Web: http://www.journals.apa.org/prevention/volume5/pre0050033r.html.Google Scholar
Kirsch, I. & Weixel, L. J. (1988). Double-blind versus deceptive administration of a placebo. Behavioral Neuroscience, 102(2), 319–23.Google Scholar
Klopfer, B. (1957). Psychological variables in human cancer. Journal of Protective Techniques, 21(4), 331–40.Google Scholar
Luchelli, P. E., Cattaneo, A. D. & Zattoni, J. (1978). European Journal of Clinical Pharmacology, 13, 153–5.
Luparello, T., Lyons, H. A., Bleecker, E. R. & McFadden, E. R. Jr. (1968). Influences of suggestion on airway reactivity in asthmatic subjects. Psychosomatic Medicine, 30(6), 819–25.Google Scholar
McFadden, E. R. Jr., Luparello, T., Lyons, H. A., Bleecker, E. & Bleecker, E. R. (1969). The mechanism of action of suggestion in the induction of acute asthma attacks: influences of suggestion on airway reactivity in asthmatic subjects. Psychosomatic Medicine, 31(2), 134–43.Google Scholar
Moerman, D. E. & Jonas, W. B. (2002). Deconstructing the placebo effect and finding the meaning response. Annals of Internal Medicine, 136, 471–6.Google Scholar
Montgomery, G. H. & Kirsch, I. (1997). Classical conditioning and the placebo effect. Pain, 72(1–2), 107–13.Google Scholar
Moseley, J. B., O'Malley, K., Petersen, N. J.et al. (2002). A controlled trial of arthroscopic surgery for osteoarthritis of the knee. New England Journal of Medicine, 347, 81–8.Google Scholar
Nagao, Y., Komia, J., Kuroanagi, K., Minaba, Y. & Susa, A. (1968). Effect of the color of analgesics on their therapeutic results. Shikwa Gakuho, 68, 139–42.Google Scholar
Neild, J. E. & Cameron, I. R. (1985). Bronchoconstriction in response to suggestion: its prevention by an inhaled anticholinergic agent. British Medical Journal (Clin Res Ed), 290(6469), 674.Google Scholar
Nitzan, U. & Lichtenberg, P. (2004). Questionnaire survey on use of placebo. British Medical Journal, 329(7472), 944–6.Google Scholar
Paul, G. L. (1966). Insight vs. desensitization in psychotherapy. Stanford, CA: Stanford University Press.
Piccione, C., Hilgard, E. R. & Zimbardo, P. G. (1989). On the degree of stability of measured hypnotizability over a 25-year period. Journal of Personality and Social Psychology, 56, 289–95.Google Scholar
Prioleau, L., Murdock, M. & Brody, N. (1983). An analysis of psychotherapy versus placebo studies. Behavioral and Brain Sciences, 6, 275–310.Google Scholar
Siegel, S. (1983). Classic conditioning, drug tolerance, and drug dependence. In Schmidt, W. (Ed.). Research advances in alcohol and drug problemsVol. 7 (pp. 207–46). New York: Plenum.
Sloane, R. B., Staples, F. R., Cristol, A. H., Yorkston, N. J. & Whipple, K. (1975). Psychotherapy versus behavior therapy. Cambridge, MA: Harvard University Press.
Smith, M. L., Glass, G. V. & Miller, T. I. (1980). The benefits of psychotherapy. Baltimore, MD: John Hopkins University Press.
Spector, S., Luparello, T. J., Kopetzky, M. T.et al. (1976). Response of asthmatics to methacholine and suggestion. American Review of Respiratory Disease, 113(1), 43–50.Google Scholar
Volgyesi, F. A. (1954). “School for patients”, hypnosis therapy and psycho prophylaxis. British Journal of Medical Hypnotism, 5, 8–17.Google Scholar
Voudouris, N. J., Peck, C. L. & Coleman, G. (1985). Conditioned placebo responses. Journal of Personality and Social Psychology, 48, 47–53.Google Scholar
Voudouris, N. J., Peck, C. L. & Coleman, G. (1989). Conditioned response models of placebo phenomena: further support. Pain, 38, 109–16.Google Scholar
Voudouris, N. J., Peck, C. L. & Coleman, G. (1990). The role of conditioning and verbal expectancy in the placebo response. Pain, 43, 121–8.Google Scholar
Wampold, B. E. (2001). The great psychotherapy debate: models, methods, and findings. Mahwah, NJ: Lawrence Erlbaum Associates.
Wampold, B. E., Minami, T., Tierney, S. C., Baskin, T. W. & Bhati, K. S. (in press). The Placebo Is Powerful: Estimating Placebo Effects in Medicine and Psychotherapy from Randomized Clinical Trials. Journal of Clinical Psychology.Google Scholar
Wickless, C. & Kirsch, I. (1989). Effects of verbal and experiential expectancy manipulations on hypnotic-susceptibility. Journal of Personality and Social Psychology, 57(5), 762–8.Google Scholar
Wolf, S., Doering, C. R., Clark, M. L. & Hagans, J. A. (1957). Chance distribution and the placebo “reactor.”Journal of Laboratory and Clinical Medicine, 49, 837–41.Google Scholar

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