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21c - Directions for Future Drug Trial Research: Author Rejoinder to Commentaries on Recent Developments in the Pharmacologic Management of Personality Disorders

from Part V - Treatment

Published online by Cambridge University Press:  24 February 2020

Carl W. Lejuez
Affiliation:
University of Kansas
Kim L. Gratz
Affiliation:
University of Toledo, Ohio
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Summary

The commentaries (this volume) stressed the need for quality research that can close the gaps between evidence and practice. The recently completed trial by Crawford and colleagues (2018) stands out as a reference point for trial methodology that will advance our understanding of the role of pharmacological management of patients with PDs. Future research trials must expand the outcomes of interest including measures that capture “clinical well-being and quality of life” and more attention to recording adverse effects. Changing functional outcomes remains one of the most challenging issues related to our current evidence-based treatment approaches for patients with PDs. The need to harmonize our approach to measuring functional improvement remains a priority for future intervention research. Pharmacological research will advance by developing a consensus on the best measures to employ, incorporating dimensional models of personality pathology and creating partnerships between patients, clinicians and care providers in order to develop a meaningful research agenda going forward.

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Publisher: Cambridge University Press
Print publication year: 2020

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References

Crawford, M. J., Sanatinia, R., Barrett, B., Cunningham, G., Dale, O., Ganguli, P., … Reilly, J. G. (2018). Lamotrigine for people with borderline personality disorder: A RCT. Health Technology Assessment, 22, 168.CrossRefGoogle ScholarPubMed
Links, P. S., Eynan, R., Heisel, M. J., Barr, A., Korzekwa, M., McMain, S., & Ball, J. S. (2007). Affective instability and suicidal ideation and behavior in patients with borderline personality disorder. Journal of Personality Disorders, 21, 7286.CrossRefGoogle ScholarPubMed
McMain, S. F., Guimond, T., Streiner, D. L., Cardish, R. J., & Links, P. S. (2012). Dialectical behavior therapy compared with general psychiatric management for borderline personality disorder: Clinical outcomes and functioning over a 2-year follow-up. American Journal of Psychiatry, 169, 650661.CrossRefGoogle ScholarPubMed

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