The most salient goals of neuroscience research on personality disorders (PDs) are to help determine the mechanisms of specific disorders and reduce the incidence and severity of personality disorders. However, authors often do not discuss neuroscience research in a context that highlights its clinical relevance. Frequently, converging evidence from clinical neuroscience could help us better characterize the mechanisms specific to personality disorders, which could be used to inform diagnosis and interventions. More pervasive efforts to describe clinical neuroscience research in terms of its clinical relevance could help better define progress made in understanding disorders, identify gaps in the research needed to be filled before the knowledge is clinically useful, and could potentially be useful to inform current clinical practice. This commentary outlines examples from Chan, Vaccaro, Rose, Kessler, and Hazlett’s review (this volume) in which the neuroscience research could be read in ways that emphasize its clinical relevance. In addition, it briefly highlights advances in neuroscience methods, as well as efforts to improve nosological systems that may help researchers in describing the clinical implications of neuroscience research.