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Chapter 10 - Cannabinoids

from Part II - Common Categories of Pharmacologic Medications to Treat Chronic Pain

Published online by Cambridge University Press:  01 December 2023

Omar Viswanath
Affiliation:
Creighton University, Omaha
Ivan Urits
Affiliation:
Southcoast Brain & Spine Center, Wareham
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Summary

The use of cannabinoids and its derivatives for chronic pain is increasing. Two most well-known and clinically relevant forms of cannabinoids are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). The main receptor targeted are cannabinoid receptor 1 (CB1) and CB2. Indications for the utilization of THC are multiple sclerosis, cancer-related pain/cancer-related nausea and vomiting (anti-emetic), peripheral neuropathic pain, and HIV-associated weight loss.

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Publisher: Cambridge University Press
Print publication year: 2023

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References

Kumar, RN, Chambers, WA, Pertwee, RG. Pharmacological actions and therapeutic uses of cannabis and cannabinoids. Anaesthesia. 2001;56(11):10591068. https://doi.org/10.1046/J.1365-2044.2001.02269.X.CrossRefGoogle ScholarPubMed
Malfitano, AM, Proto, MC, Bifulco, M. Cannabinoids in the management of spasticity associated with multiple sclerosis. Neuropsychiatr. Dis. Treat. 2008;4(5):847. https://doi.org/10.2147/NDT.S3208.Google ScholarPubMed
EPIDIOLEX® (cannabidiol) | Greenwich Biosciences. 2021. Accessed November 5, 2021. www.greenwichbiosciences.com/epidiolex.Google Scholar
O’Donnell, B, Meissner, H, Gupta, V. Dronabinol. Pharma-Kritik. 2021;24(8):2931. Accessed November 5, 2021. www.ncbi.nlm.nih.gov/books/NBK557531/.Google Scholar
Ware, MA, Daeninck, P, Maida, V. A review of nabilone in the treatment of chemotherapy-induced nausea and vomiting. Ther. Clin. Risk Manag. 2008;4(1):99. https://doi.org/10.2147/TCRM.S1132.CrossRefGoogle ScholarPubMed
Grotenhermen, F, Müller-Vahl, K. The Therapeutic Potential of Cannabis and Cannabinoids. Deutsches Ärzteblatt International. 2012;109(29–30):495. https://doi.org/10.3238/ARZTEBL.2012.0495.Google ScholarPubMed
Russo, M, Naro, A, Leo, A et al. Evaluating Sativex® in neuropathic pain management: A clinical and neurophysiological assessment in multiple sclerosis. Pain Med. (Malden, Mass). 2016;17(6):11451154. https://doi.org/10.1093/PM/PNV080.Google ScholarPubMed
Serpell, MG, Notcutt, W, Collin, C. Sativex long-term use: An open-label trial in patients with spasticity due to multiple sclerosis. J. Neurol. 2013;260(1):285295. https://doi.org/10.1007/S00415-012-6634-Z.CrossRefGoogle ScholarPubMed
Sheikh, NK, Dua, A. Cannabinoids. Published online July 25, 2021. Accessed November 5, 2021. www.ncbi.nlm.nih.gov/books/NBK556062/.Google Scholar

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