The date of this letter is unknown, though it is later than the First Letter to Succensus. It could almost be regarded as the charter of the miaphysite movement that would crystalize after the Council of Chalcedon and persists to the present day. Here Cyril responds directly to a series of questions presented to Succensus by an unspecified person from the camp of the Easterners (so called because they came from the Roman diocese of Oriens or “East”), presumably in response to what he had written in the First Letter to Succensus. Notably all of the questions turn on the issue of what the words “flesh” (sarx) or “become incarnate” (ensarkoō) mean and what they imply about how one should use the language of “nature” (physis) with respect to Christ.