The first ladies of the United States are often not thought about as activists. But in fact, many used their political position strategically to advocate for important reforms that benefited minorities and other underrepresented groups. Their activism from the White House helped social and political causes in different eras. Their unsung work contributed to their administration’s public profile and legacy. It also aided larger social justice campaigns going on throughout US history. This chapter explores the frequently unsung efforts of US first ladies in the realm of social advocacy to shed greater light on the significant work done by these women. It challenges the notion that first ladies were simply ornaments or companions for their husbands and highlights the actions that they took to create change.