The role of international diplomat developed for first ladies post–World War II. Although Edith Wilson and Eleanor Roosevelt set precedents, Jacqueline Kennedy solidified protocols for diplomatic behavior during the Cold War. First ladies use soft diplomacy as a counterbalance to military policy to advance civil society and democracy. This chapter examines travel as state diplomacy, skill in interpersonal relationship building, fashion and cultural diplomacy, and issue-based negotiation. Analysis includes Pat Nixon’s humanitarian travel and support of détente with China, Rosalynn Carter as surrogate president in Latin America and encourager of Middle East peace, Nancy Reagan as promoter of US–Soviet relations to end the Cold War, Hillary Clinton as a champion of women’s rights as human rights, Laura Bush’s support for Afghan women and girls, and Michelle Obama’s international efforts to promote girls’ education. These exemplary women indicate the power of first ladies to advance progress in education, health, foreign policy, and human rights.