This chapter distinguishes two ways in which the Middle Ages conceived the relationship between human and nonhuman creatures. The first, according to which humans are a unique kind of animal (in the Latin word’s sense of “living being”), is available primarily to the learned, whereas the second, widely attested in lay usage and practice, concerns the difference (or lack of it) between humans and “beasts.” The chapter explores the complication of both relationships in the French and English romances of William of Palermo (late twelfth-/early thirteenth-century and mid-fourteenth-century, respectively), in which one aristocratic protagonist is turned into a werewolf and others disguise themselves in the skins of bear or deer. Human exceptionalism appears to condition the story’s coding of social dysfunction as animalization, but the romances equally show medieval aristocratic and chivalric identity embracing its proximity to “beasts,” for example, in the notion of sovereignty, in the symbolic languages of heraldry and dreams, and in moments of explicit self-identification. The chapter concludes by arguing that the way these romances build their fiction with reference to animals is materialized in the manuscript books that transmit them, made up as they are of parchment pages, that is, of processed animal skins.