MNCs have a central role, responsibility, and opportunity to foment change globally in fulfilling the rights of persons with disabilities. In addition to improving theiremployment practices, MNCs can leverage their economic power to fulfil other aspects of the human rights of persons with disabilities within their purview by: making physical and virtual environments accessible; ensuring that vendors, distributors and supply chains require equal employment opportunity for workers with a disability, produce accessible products and services, and take affirmative actions to employ and advance in employment workers with a disability; acknowledging the existence and value of customers with disabilities and their households and friends; marketing to such individuals; developing data accumulation and accountability instruments, including human rights impact assessments (HRIAs); and creating a general culture of diversity, equity, and inclusion of differences that includes disability. Acting in this manner would bolster rarely helpful corporate social responsibility (CSR) and diversity schemes, and position the business sector to become human rights change agents.