,American Cancer Society. Cancer Facts and Figures 2007. Atlanta: American Cancer Society; 2007.Google Scholar

Miniño, AM, Heron, MP, Smith, BL. Deaths: Preliminary Data for 2004. National Vital Statistics Report. 2006 June 28;54(19).

,American Cancer Society. Cancer Facts and Figures 2005. Atlanta: American Cancer Society; 2005.Google Scholar

Edwards, BK, Brown, ML, Wingo, PA, Howe, HL, Ward, E, Ries, LAG, et al. Annual Report to the Nation on the Status of Cancer, 1975–2002, Featuring Population-Based Trends in Cancer Treatment. Journal of the National Cancer Institute. 2005 October 5; 97(19).CrossRefGoogle ScholarPubMed

,WHO. Mortality: Revised Global Burden of Disease (2002) Estimates. Geneva: World Health Organization; 2002.Google Scholar

Parkin, DM, Bray, F, Ferlay, J, Pisani, P. Global cancer statistics, 2002. CA: a Cancer Journal for Clinicians. 2005 Mar–Apr; 55(2): 74–108.Google ScholarPubMed

,International Union Against Cancer. Global Action Against Cancer. Geneva: WHO/UICC; 2005.Google Scholar

,World Health Organization. Global Cancer Rates Could Increase by 50% to 15 Million by 2020. Geneva: World Health Organization; 2003 April 3.Google Scholar

,American Cancer Society. The Case for Global Action. 2007 [cited 2007 May 9]; Available from: http://www.cancer.org/docroot/AA/content/AA_2_5_1x_Case_for_Global_Action.asp?sitearea=AA

,American Cancer Society. Lifetime Probability of Developing or Dying from Cancer. 2006 February 22 [cited 2007 May 9]; Available from: http://www.cancer.org/docroot/CRI/content/CRI_2_ 6x_Lifetime_Probability_of_Developing_or_Dying_From_Cancer.asp?sitearea=

Stewart, BW, Kleihues, P, eds. World Cancer Report. Lyon: IARC Press; 2003.

,American Cancer Society. Cancer Statistics 2005 [PowerPoint]. Atlanta: American Cancer Society; 2005.Google Scholar

MacKay, J, Eriksen, M. The Tobacco Atlas. Geneva: The World Health Organization; 2002.Google Scholar

,American Cancer Society. Cancer Prevention and Early Detection Facts and Figures 2007. Atlanta: American Cancer Society; 2007.Google Scholar

Hanahan, D, Weinberg, RA. The hallmarks of cancer. Cell. 2000 Jan 7; 100(1): 57–70.CrossRefGoogle ScholarPubMed

,Dolan DNA Learning Center – Cold Spring Harbor Laboratory. Inside Cancer. [Multimedia Guide] 2004 [cited 2007 May 10]; Available from: www.insidecancer.org

Cotran, RS, Kumar, V, Robbins, SL. Robbins Pathologic Basis of Disease. 5th edn. W.B. Saunders Company; 1994.Google Scholar

,National Cancer Institute. Milestone (1971): President Nixon declares war on cancer. 2007 [cited 2007 May 10]; Available from: http://dtp.nci.nih.gov/timeline/noflash/milestones/M4_Nixon.htm

Niederhuber, JE. The Nation's Investment in Cancer Research. Frederick, Maryland: National Cancer Institute; 2006 October.Google Scholar

,National Cancer Institute. The NCI Strategic Plan for Leading the Nation. Frederick, Maryland: National Cancer Institute; 2006 January.Google Scholar

,National Center for Health Statistics. Health, United States, 2006 With Chartbook on Trends in the Health of Americans. Hyattsville, MD; 2006.Google Scholar

Carr, DB, Loeser, JD, Morris, DB. Narrative, Pain and Suffering (Progress in Pain Research and Management). Seattle, WA: IASP Press; 2005.Google Scholar

Wang, XS, Li, TD, Yu, SY, Gu, WP, Xu, GW. China: status of pain and palliative care. Journal of Pain and Symptom Management. 2002 Aug; 24(2): 177–9.CrossRefGoogle ScholarPubMed

,US Preventive Services Task Force. Guide to Clinical Preventive Services. 2nd edn. Alexandria, VA: International Medical Publishing; 1996.Google Scholar

Elmore, JG, Armstrong, K, Lehman, CD, Fletcher, SW. Screening for breast cancer. Jama. 2005 Mar 9; 293(10): 1245–56.CrossRefGoogle ScholarPubMed

Warner, E, Plewes, DB, Hill, KA, Causer, PA, Zubovits, JT, Jong, RA, et al. Surveillance of BRCA1 and BRCA2 mutation carriers with magnetic resonance imaging, ultrasound, mammography, and clinical breast examination. Jama. 2004 Sep 15; 292(11): 1317–25.CrossRefGoogle ScholarPubMed

Thomas, DB, Gao, DL, Ray, RM, Wang, WW, Allison, CJ, Chen, FL, et al. Randomized trial of breast self-examination in Shanghai: final results. Journal of the National Cancer Institute. 2002 Oct 2;94(19): 1445–57.CrossRefGoogle ScholarPubMed

,American Cancer Society. Cancer Facts and Figures 2006. Atlanta: American Cancer Society; 2006.Google Scholar

Humphrey, LL, Helfand, M, Chan, BK, Woolf, SH. Breast cancer screening: a summary of the evidence for the US Preventive Services Task Force. Annals of Internal Medicine. 2002 Sep 3; 137(5 Part 1): 347–60.CrossRefGoogle Scholar

Parkin, DM, Bray, F. Chapter 2: The burden of HPV-related cancers. Vaccine. 2006 Aug 21; 24 Suppl. 3: S11–25.CrossRefGoogle ScholarPubMed

Nijhuis, ER, Reesink-Peters, N, Wisman, GB, Nijman, HW, Zanden, J, Volders, H, et al. An overview of innovative techniques to improve cervical cancer screening. Cell Oncology. 2006; 28(5–6): 233–46.Google ScholarPubMed

Burchell, AN, Richardson, H, Mahmud, SM, Trottier, H, Tellier, PP, Hanley, J, et al. Modeling the sexual transmissibility of human papillomavirus infection using stochastic computer simulation and empirical data from a cohort study of young women in Montreal, Canada. American Journal of Epidemiology. 2006 Mar 15; 163(6): 534–43.CrossRefGoogle ScholarPubMed

,American Cancer Society. FDA Approves New Cervical Cancer Screening Test. 2003 March 31 [cited 2007 May 10]; Available from: http://www.cancer.org/docroot/NWS/content/NWS_1_1x_FDA_Approves_New_Cervical_Cancer_Screening_Test.asp

Cohen, J. Public health. High hopes and dilemmas for a cervical cancer vaccine. Science (New York, NY). 2005 Apr 29; 308(5722): 618–21.CrossRefGoogle ScholarPubMed

Alberts, B. Molecular Biology of the Cell. 3rd edn. New York: Garland Publishing; 1994.Google Scholar

Renshaw, AA. Measuring sensitivity in gynecologic cytology: a review. Cancer. 2002 Aug 25; 96(4): 210–17.CrossRefGoogle ScholarPubMed

,Centers for Disease Control. Regulations for Implementing the Clinical Laboratory Improvement Amendments of 1988: a Summary. MMWR. 1992 (No. RR-2).

Austin, RM. Human papillomavirus reporting: minimizing patient and laboratory risk. Archives of Pathology & Laboratory Medicine. 2003 Aug; 127(8): 973–7.Google ScholarPubMed

Bogdanich, W. Lax Laboratories: The Pap Test misses much cervical cancer through lab's errors. The Wall Street Journal. 1987 November 2.Google Scholar

Nanda, K, McCrory, DC, Myers, ER, Bastian, , Hasselblad, V, Hickey, JD, et al. Accuracy of the Papanicolaou test in screening for and follow-up of cervical cytologic abnormalities: a systematic review. Annals of Internal Medicine. 2000 May 16; 132(10): 810–19.CrossRefGoogle ScholarPubMed

Fahey, MT, Irwig, L, Macaskill, P. Meta-analysis of Pap test accuracy. American Journal of Epidemiology. 1995 Apr 1; 141(7): 680–9.CrossRefGoogle ScholarPubMed

Mitchell, MF, Schottenfeld, D, Tortolero-Luna, G, Cantor, SB, Richards-Kortum, R. Colposcopy for the diagnosis of squamous intraepithelial lesions: a meta-analysis. Obstetrics and Gynecology. 1998 Apr; 91(4): 626–31.Google Scholar

Welch, HG. Should I be Tested for Cancer?Berkely, CA: University of California Press; 2004.Google Scholar

Ferenczy, A, Franco, E. Cervical-cancer screening beyond the year 2000. The Lancet Oncology. 2001 Jan; 2(1): 27–32.CrossRefGoogle ScholarPubMed

Hutchinson, ML. Assessing the costs and benefits of alternative rescreening strategies. Acta Cytologica. 1996 Jan–Feb; 40(1): 4–8.Google ScholarPubMed

Kurman, RJ, Henson, , Herbst, AL, Noller, KL, Schiffman, MH. Interim guidelines for management of abnormal cervical cytology. The 1992 National Cancer Institute Workshop. Jama. 1994 Jun 15; 271(23): 1866–9.CrossRefGoogle ScholarPubMed

Jeronimo, J, Morales, O, Horna, J, Pariona, J, Manrique, J, Rubinos, J, et al. Visual inspection with acetic acid for cervical cancer screening outside of low-resource settings. Revista Panamericana de Salud Publica (Pan American Journal of Public Health). 2005 Jan; 17(1): 1–5.Google ScholarPubMed

Birdsong, GG. Automated screening of cervical cytology specimens. Human Pathology. 1996 May; 27(5): 468–81.CrossRefGoogle ScholarPubMed

Groopman, J. Contagion: Papilloma Virus. The New Yorker. 1999 September 13.Google Scholar

Saslow, D, Runowicz, CD, Solomon, D, Moscicki, AB, Smith, RA, Eyre, HJ, et al. American Cancer Society guideline for the early detection of cervical neoplasia and cancer. CA: a Cancer Journal for Clinicians. 2002 Nov–Dec; 52(6): 342–62.Google ScholarPubMed

Russell, J, Crothers, BA, Kaplan, KJ, Zahn, CM. Current cervical screening technology considerations: liquid-based cytology and automated screening. Clinical Obstetrics and Gynecology. 2005 Mar; 48(1): 108–19.CrossRefGoogle ScholarPubMed

,Health Technologies Advisory Committee – Minnesota. New technologies for cervical cancer screening: strategies to lower the rate of cervical cancer. Health Services/Technology Assessment Text (HSTAT). National Library of Medicine; 1999.Google Scholar

,FDA. FDA Approves Expanded Use of HPV Test. 2003 March 31 [cited 2007 May 20]; Available from: http://www.fda.gov/bbs/topics/NEWS/2003/NEW00890.html

Schiffman, M, Herrero, R, Hildesheim, A, Sherman, ME, Bratti, M, Wacholder, S, et al. HPV DNA testing in cervical cancer screening: results from women in a high-risk province of Costa Rica. Jama. 2000 Jan 5; 283(1): 87–93.CrossRefGoogle Scholar

Arbyn, M, Sasieni, P, Meijer, CJ, Clavel, C, Koliopoulos, G, Dillner, J. Chapter 9: Clinical applications of HPV testing: a summary of meta-analyses. Vaccine. 2006 Aug 21; 24 Suppl. 3: S78–89.CrossRefGoogle ScholarPubMed

,Digene Corporation. Hybrid Capture® 2 High-Risk HPV DNA TestTM [cited 2007 May 20]; Product Insert]. Available from: http://www.digene.com/pdf/L2290-P.I,%20hc2%20HPV%20DNA%20Test%20US.pdf

Germar, MJ, Marialdi, M. Visual inspection with acetic acid as a cervical cancer screening tool for developing countries. Review for the 12th Postgraduate Training Course in Reproductive Health/Chronic Disease 2003 [cited 2007 May 28]; Available from: http://www. gfmer.ch/Endo/Course2003/Visual_inspection_cervical_ cancer.htmGoogle Scholar

,Coalition NCC. NCCC Section on the HPV Vaccine. 2007 [cited 2007 March 2]; Available from: http://www.nccc-online.org/hpv-vaccine.php

Cohen, J. High hopes and dilemmas for a cervical cancer vaccine. Science (New York, NY). 2003; 308: 618–21.CrossRefGoogle Scholar

Kane, MA, Sherris, J, Coursaget, P, Aguado, T, Cutts, F. Chapter 15: HPV vaccine use in the developing world. Vaccine. 2006 Aug 21; 24 Suppl. 3: S132–9.CrossRefGoogle ScholarPubMed

Sankaranarayanan, R, Shastri, SS, Basu, P, Mahe, C, Mandal, R, Amin, G, et al. The role of low-level magnification in visual inspection with acetic acid for the early detection of cervical neoplasia. Cancer Detection and Prevention. 2004; 28(5): 345–51.CrossRefGoogle ScholarPubMed

,Pan American Health Organization. Visual Inspection of the Uterine Cervix with Acetic Acid (VIA): A Critical Review and Selected Articles. Washington, D.C.; 2003.Google Scholar

Park, SY, Follen, M, Milbourne, A, Rhodes, H, Malpica, A, MacKinnon, M, et al. Automated image analysis of digital colposcopy for the detection of cervical neoplasia. Manuscript submitted for publication, 2007.

Kasper, D, Braunwald, E, Fauci, A, Longo, D, Hauser, S, Jameson, JL, eds. Harrison's Principles of Internal Medicine. 16th edn. New York City: McGraw-Hill; 2005.

Hutchinson, K, Wener, M. National Health and Nutrition Examination Survey Lab Methods 2003–2004: Total Prostate-Specific Antigen (PSA). University of Washington Medical Center; 2007 May 4.Google Scholar

,Aureon Biosystems. LumiPhos Plus. [cited 2007 March 10]; Available from: http://www.aureonbio.com/ProductList.htm

,Lumigen. Lumigen PPD. 2006 [cited 2007 March 10]; Available from: http://www.lumigen.com/documents/LumigenPPD.shtml

Hernandez, J, Thompson, IM. Prostate-specific antigen: a review of the validation of the most commonly used cancer biomarker. Cancer. 2004 Sep 1; 101(5): 894–904.CrossRefGoogle ScholarPubMed

Albertsen, PC. Is screening for prostate cancer with prostate specific antigen an appropriate public health measure?Acta Oncologica (Stockholm, Sweden). 2005; 44(3): 255–64.CrossRefGoogle ScholarPubMed

Gottlieb, RH, Mooney, C, Mushlin, AI, Rubens, DJ, Fultz, PJ. The prostate: decreasing cost-effectiveness of biopsy with advancing age. Investigative Radiology. 1996 Feb; 31(2): 84–90.CrossRefGoogle ScholarPubMed

,American Cancer Society. How Is Prostate Cancer Diagnosed? 2006 July 26 [cited 2007 May 20]; Available from: http://www.cancer.org/docroot/CRI/content/CRI_2_4_3X_How_is_prostate_cancer_diagnosed_36.asp

Lu-Yao, GL, Yao, SL. Population-based study of long-term survival in patients with clinically localised prostate cancer. The Lancet. 1997 Mar 29; 349(9056): 906–10.CrossRefGoogle ScholarPubMed

Neal, , Leung, HY, Powell, PH, Hamdy, FC, Donovan, JL. Unanswered questions in screening for prostate cancer. European Journal of Cancer. 2000 Jun; 36(10): 1316–21.CrossRefGoogle ScholarPubMed

Bartsch, G, Horninger, W, Klocker, H, Reissigl, A, Oberaigner, W, Schonitzer, D, et al. Prostate cancer mortality after introduction of prostate-specific antigen mass screening in the Federal State of Tyrol, Austria. Urology. 2001 Sep; 58(3): 417–24.CrossRefGoogle ScholarPubMed

Horninger, W, Berger, A, Pelzer, A, Klocker, H, Oberaigner, W, Schonitzer, D, et al. Screening for prostate cancer: updated experience from the Tyrol study. The Canadian Journal of Urology. 2005 Feb; 12 Suppl. 1: 7–13; discussion 92–3.Google ScholarPubMed

Ilic, D, O'Connor, D, Green, S, Wilt, T. Screening for prostate cancer: a Cochrane systematic review. Cancer Causes Control. 2007 Apr; 18(3): 279–85.CrossRefGoogle ScholarPubMed

Amling, CL. Prostate-specific antigen and detection of prostate cancer: what have we learned and what should we recommend for screening?Current Treatment Options in Oncology. 2006 Sep; 7(5): 337–45.CrossRefGoogle ScholarPubMed

Hennekens, CH, Buring, JE. Epidemiology In Medicine. Philadelphia: Lippincott Williams & Wilkins; 1987.Google Scholar

Welch, HG, Schwartz, LM, Woloshin, S. Are increasing 5-year survival rates evidence of success against cancer?Jama. 2000 Jun 14; 283(22): 2975–8.CrossRefGoogle ScholarPubMed

Reynolds, EA, Moller, KA. A review and an update on the screening of epithelial ovarian cancer. Current Problems in Cancer. 2006 Sep–Oct; 30(5): 203–32.CrossRefGoogle ScholarPubMed

Rosenthal, AN, Menon, U, Jacobs, IJ. Screening for ovarian cancer. Clinical Obstetrics and Gynecology. 2006 Sep; 49(3): 433–47.CrossRefGoogle ScholarPubMed

,BC Cancer Agency. Years of Life Lost. 2005 July 25 [cited 2007 May 22]; Available from: http://www.bccancer.bc.ca/HPI/CancerStatistics/FF/LifeLost.htm

Petricoin, EF, Ardekani, AM, Hitt, BA, Levine, PJ, Fusaro, VA, Steinberg, SM, et al. Use of proteomic patterns in serum to identify ovarian cancer. The Lancet. 2002 Feb 16; 359(9306): 572–7.CrossRefGoogle ScholarPubMed

Urban, N. Specific keynote: ovarian cancer risk assessment and the potential for early detection. Gynecologic Oncology. 2003 Jan; 88(1 Pt 2): S75–9; discussion S80–3.CrossRefGoogle ScholarPubMed

Nahhas, WA. Ovarian cancer. Current outlook on this deadly disease. Postgraduate Medicine. 1997 Sep; 102(3): 112–20.CrossRefGoogle ScholarPubMed

Zurawski, VR, Jr., Sjovall, K, Schoenfeld, DA, Broderick, SF, Hall, P, Bast, RC, Jr., et al. Prospective evaluation of serum CA 125 levels in a normal population, phase I: the specificities of single and serial determinations in testing for ovarian cancer. Gynecologic Oncology. 1990 Mar; 36(3): 299–305.CrossRefGoogle Scholar

Gladstone, CQ. Screening for ovarian cancer. In: ,Canadian Task Force on Periodic Health Examination, ed. Canadian Guide to Clinical Preventive Health Care. Ottawa: Health Canada; 1994: 870–81.Google Scholar

Menon, U, Jacobs, IJ. Ovarian cancer screening in the general population. Current Opinion in Obstetrics & Gynecology. 2001 Feb; 13(1): 61–4.CrossRefGoogle ScholarPubMed

Nagell, JR, DePriest, PD, Reedy, MB, Gallion, HH, Ueland, FR, Pavlik, EJ, et al. The efficacy of transvaginal sonographic screening in asymptomatic women at risk for ovarian cancer. Gynecologic Oncology. 2000 Jun; 77(3): 350–6.CrossRefGoogle ScholarPubMed

Lok, IH, Sahota, DS, Rogers, MS, Yuen, PM. Complications of laparoscopic surgery for benign ovarian cysts. The Journal of the American Association of Gynecologic Laparoscopists. 2000 Nov; 7(4): 529–34.CrossRefGoogle ScholarPubMed

Hensley, ML, Spriggs, . Cancer screening: how good is good enough? Journal of Clinical Oncology. 2004 Oct 15; 22(20): 4037–9.CrossRefGoogle ScholarPubMed

Johnson, D, Sandmire, D, Klein, D. Ovarian Cancer. In Medical Tests That Can Save Your Life: 21 Tests Your Doctor Won't Order Unless You Know to Ask. Emmaus, PA Rodale; 2004.Google Scholar

Fees Involved in Infertility Treatments. 2005 [cited 2007 June 1]; Available from: http://www.sharedjourney.com/articles/eggfees.html

Jacobs, IJ, Skates, S, Davies, AP, Woolas, RP, Jeyerajah, A, Weidemann, P, et al. Risk of diagnosis of ovarian cancer after raised serum CA 125 concentration: a prospective cohort study. BMJ (Clinical Research Ed.) 1996 Nov 30; 313(7069): 1355–8.CrossRefGoogle ScholarPubMed

Jacobs, IJ, Skates, SJ, MacDonald, N, Menon, U, Rosenthal, AN, Davies, AP, et al. Screening for ovarian cancer: a pilot randomised controlled trial. The Lancet. 1999 Apr 10; 353(9160): 1207–10.CrossRefGoogle ScholarPubMed

UK Collaborative Trial of Ovarian Cancer Screening. 2006 July 11 [cited 2007 May 20]; Available from: http://www.ukctocs.org.uk/index.html

Buys, SS, Partridge, E, Greene, MH, Prorok, PC, Reding, D, Riley, TL, et al. Ovarian cancer screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial: findings from the initial screen of a randomized trial. American Journal of Obstetrics and Gynecology. 2005 Nov; 193(5): 1630–9.CrossRefGoogle ScholarPubMed

,FDA. Protein Patterns May Identify Ovarian Cancer. 2002 February 7 [cited 2007 May 20]; Available from: http://www.fda.gov/bbs/topics/NEWS/2002/NEW00797.html

Pollack, A. New cancer test stirs hope and concern. The New York Times. 2004 February 3.Google Scholar

Underwood, A. Testing: ovarian cancer. Newsweek. 2002 February 18: 12.Google Scholar

Baggerly, KA, Morris, JS, Coombes, KR. Reproducibility of SELDI-TOF protein patterns in serum: comparing datasets from different experiments. Bioinformatics (Oxford, England). 2004 Mar 22; 20(5): 777–85.CrossRefGoogle ScholarPubMed

,American Cancer Society, How Many People Get Lung Cancer, 2004; Available from: http://www.cancer.org/docroot/CRI/content/CRI_2_2_IX_How_many_people_get_lung_cancer_26.asp?sitearea=

www.med.uiuc.edu/m2/epidemiology/ReviewQuestions/SensitivitySpecificity_Questions.htm.