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14 - Disrupted Circadian Rhythms and Cancer

Published online by Cambridge University Press:  07 October 2023

By
Baharan Fekry  and
Kristin Eckel-Mahan
Edited by
Laura K. Fonken  and
Randy J. Nelson
Laura K. Fonken
Affiliation:
University of Texas, Austin
Randy J. Nelson
Affiliation:
West Virginia University
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Summary

A growing number of studies reveal that disruption of the endogenous, circadian (i.e., 24-hour) clock increases the risk for acquiring several diseases, including specific cancers. Significantly more work needs to be done to understand the molecular substrates involved in the mechanistic links between circadian clock disruption and cancer initiation and progression. Of particular complexity remains the contribution of the circadian clock in individual cells during the process of transformation (cancer initiation) versus its function in tumor-surrounding stroma and how this affects the process of tumor progression or metastasis. This chapter reviews some of the basic mechanisms understood to link circadian disruption and cancer at the level of gene expression and metabolism, while highlighting human studies supporting the association between circadian disruption and cancer incidence. In light of what is currently known, tremendous opportunites exist to use circadian approaches for future prevention and treatment strategies in the context of organ-specific cancer.

Keywords

chronotherapybreast cancerhepatocellular carcinomachronodisruptionclock genes
Type
Chapter
Information
Biological Implications of Circadian Disruption
A Modern Health Challenge
 , pp. 310 - 337
Publisher: Cambridge University Press
Print publication year: 2023

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