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1 - The Eternal Youth of Ageing Research

Published online by Cambridge University Press:  14 November 2024

By
Jean-François Lemaître  and
Samuel Pavard
Edited by
Jean-François Lemaître  and
Samuel Pavard
Jean-François Lemaître
Affiliation:
Centre National de la Recherche Scientifique (CNRS)
Samuel Pavard
Affiliation:
National Museum of Natural History, Paris
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Summary

This opening chapter provides an overview of the future societal and subsequenl scientific challenges associated with population ageing. More specifically, it emphasizes how the field of biodemography constitutes a relevant framework for future research programmes aiming to address questions of paramount importance regarding both the causes (e.g. evolutionary, mechanistics) and consequences (demographic, medical) of the ageing process. Finally, this chapter details the book contents.

Keywords

biodemographylifespanlongevitymulti-disciplinaritysenescence
Type
Chapter
Information
The Biodemography of Ageing and Longevity , pp. 1 - 11
Publisher: Cambridge University Press
Print publication year: 2024

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References

Oeppen, J., Vaupel, J.W. 2002. Broken limits to life expectancy. Science 296, 1029–1031 (doi:10.1126/science.1069675).CrossRefGoogle ScholarPubMed
Vallin, J., Meslé, F. 2009. The segmented trend line of highest life expectancies. Popul. Dev. Rev. 35, 159–187 (doi:10.1111/j.1728-4457.2009.00264.x).CrossRefGoogle Scholar
UNECE (United Nations Economic Commission for Europe). 2006. What UNECE does for you: challenges and opportunities of population ageing. https://unece.org/info/Population/pub/2775.Google Scholar
Dong, X., Milholland, B., Vijg, J. 2016. Evidence for a limit to human lifespan. Nature 538, 257–259.CrossRefGoogle ScholarPubMed
Marck, A., Antero, J., Berthelot, G., Saulière, G., Jancovici, J.-M., Masson-Delmotte, V., Boeuf, G., Spedding, M., Le Bourg, É., Toussaint, J.-F. 2017. Are we reaching the limits of Homo sapiens? Front. Physiol. 8, 812.CrossRefGoogle ScholarPubMed
United Nations. 2023. Transforming our world: the 2030 Agenda for Sustainable Development. Sustainable Development Knowledge Platform. https://sustainabledevelopment.un.org/post2015/transformingourworld/publication.Google Scholar
Alejandria-Ganzales, M.C.P., Ghosh, S., Sacco, N. 2019. Aging in the Global South: Challenges and Opportunities. Lexington Books.Google Scholar
WHO (World Health Organization). 2022. The decade in a climate-changing world. Decade of Healthy Ageing Connection Series No. 3. www.who.int/publications/m/item/decade-of-healthy-ageing-connection-series-no3.Google Scholar
Olshansky, S.J. 2021. Aging like Struldbruggs, Dorian Gray or Peter Pan. Nat. Aging 1, 576–578.CrossRefGoogle ScholarPubMed
Horiuchi, S. 1999. Epidemiological transitions in human history. Health Mortal. Issues Glob. Concern, 54–71. (Reprinted in Watson, Jonathan, Ovseiko, Pavel, eds. 2005. Health Care Systems: Major Themes in Health and Social Welfare. Volume 4. Rethinking Health Care Systems, pp. 109–135. Routledge.)Google Scholar
United Nations, Department of Economic and Social Affairs, Population Division. 2022. World Population Prospects. Online Edition. https://population.un.org/wpp/.Google Scholar
Carey, J.R., Roach, D.A. 2020. Biodemography: An Introduction to Concepts and Methods. Princeton University Press.Google Scholar
Jones, O.R., Scheuerlein, A., Salguero-Gómez, R., Camarda, C.G., Schaible, R., Casper, B.B., Dahlgren, J.P., Ehrlén, J., García, M.B., Menges, E.S. 2014. Diversity of ageing across the tree of life. Nature 505, 169.CrossRefGoogle ScholarPubMed
Lu, A.T. et al. 2023. Universal DNA methylation age across mammalian tissues. Nat. Aging 3, 1144–1166 (doi:10.1038/s43587-023-00462-6).CrossRefGoogle ScholarPubMed
Nussey, D.H., Froy, H., Lemaître, J.-F., Gaillard, J.-M., Austad, S.N. 2013. Senescence in natural populations of animals: widespread evidence and its implications for bio-gerontology. Ageing Res. Rev. 12, 214–225.CrossRefGoogle ScholarPubMed
Shefferson, R.P., Jones, O.R., Salguero-Gómez, R. 2017. The Evolution of Senescence in the Tree of Life. Cambridge University Press.CrossRefGoogle Scholar
Reinke, B.A., Cayuela, H., Janzen, F.J., Lemaître, J.-F., Gaillard, J.-M., Lawing, A.M., Iverson, J.B., Christiansen, D.G., Martínez-Solano, I., Sánchez-Montes, G. 2022. Diverse aging rates in ectothermic tetrapods provide insights for the evolution of aging and longevity. Science 376, 1459–1466.CrossRefGoogle ScholarPubMed
Gaillard, J.-M., Lemaître, J.-F. 2020. An integrative view of senescence in nature. Funct. Ecol. 34, 4–16.CrossRefGoogle Scholar
Flatt, T., Partridge, L. 2018. Horizons in the evolution of aging. BMC Biol. 16, 93 (doi:10.1186/s12915-018-0562-z).CrossRefGoogle ScholarPubMed
Hoekstra, L.A., Schwartz, T.S., Sparkman, A.M., Miller, D.A.W., Bronikowski, A.M. 2020. The untapped potential of reptile biodiversity for understanding how and why animals age. Funct. Ecol. 34, 38–54 (doi:10.1111/1365-2435.13450).CrossRefGoogle ScholarPubMed
Voituron, Y., Guillaume, O., Dumet, A., Zahn, S., Criscuolo, F. 2023. Temperature-independent telomere lengthening with age in the long-lived human fish (Proteus anguinus). Proc. R. Soc. B 290, 20230503.CrossRefGoogle ScholarPubMed
Natterson-Horowitz, B., Aktipis, A., Fox, M., Gluckman, P.D., Low, F.M., Mace, R., Read, A., Turner, P.E., Blumstein, D.T. 2023. The future of evolutionary medicine: sparking innovation in biomedicine and public health. Front. Sci. 1, 997136.CrossRefGoogle ScholarPubMed
Gorbunova, V., Seluanov, A., Zhang, Z., Gladyshev, V.N., Vijg, J. 2014. Comparative genetics of longevity and cancer: insights from long-lived rodents. Nat. Rev. Genet. 15, 531.CrossRefGoogle ScholarPubMed
Cayuela, H., Lemaître, J.-F., Muths, E., McCaffery, R.M., Frétey, T., Le Garff, B., Schmidt, B.R., Grossenbacher, K., Lenzi, O., Hossack, B.R. 2021. Thermal conditions predict intraspecific variation in senescence rate in frogs and toads. Proc. Natl. Acad. Sci. 118, e2112235118.CrossRefGoogle ScholarPubMed
Dupoué, A. et al. 2022. Lizards from warm and declining populations are born with extremely short telomeres. Proc. Natl. Acad. Sci. 119, e2201371119.CrossRefGoogle ScholarPubMed
Robert, A., Chantepie, S., Pavard, S., Sarrazin, F., Teplitsky, C. 2015. Actuarial senescence can increase the risk of extinction of mammal populations. Ecol. Appl. 25, 116–124.CrossRefGoogle ScholarPubMed
Leyva, E.W.A., Beaman, A., Davidson, P.M. 2017. Health impact of climate change in older people: an integrative review and implications for nursing. J. Nurs. Scholarsh. 49, 670–678 (doi:10.1111/jnu.12346).CrossRefGoogle ScholarPubMed
Weon, B.M. 2016. Tyrannosaurs as long-lived species. Sci. Rep. 6, 19554.CrossRefGoogle ScholarPubMed
Romiguier, J., Ranwez, V., Douzery, E.J., Galtier, N. 2013. Genomic evidence for large, long-lived ancestors to placental mammals. Mol. Biol. Evol. 30, 5–13.CrossRefGoogle ScholarPubMed
Clutton-Brock, T., Sheldon, B.C. 2010. Individuals and populations: the role of long-term, individual-based studies of animals in ecology and evolutionary biology. Trends Ecol. Evol. 25, 562–573.CrossRefGoogle ScholarPubMed
Deelen, J., Evans, D.S., Arking, D.E., Tesi, N., Nygaard, M., Liu, X., Wojczynski, M.K., Biggs, M.L., van Der Spek, A., Atzmon, G. 2019. A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat. Commun. 10, 3669.CrossRefGoogle ScholarPubMed
Hillary, R.F., Stevenson, A.J., Cox, S.R., McCartney, D.L., Harris, S.E., Seeboth, A., Higham, J., Sproul, D., Taylor, A.M., Redmond, P. 2021. An epigenetic predictor of death captures multi-modal measures of brain health. Mol. Psychiatry 26, 3806–3816.CrossRefGoogle ScholarPubMed
López-Otín, C., Blasco, M.A., Partridge, L., Serrano, M., Kroemer, G. 2023. Hallmarks of aging: an expanding universe. Cell 186, 243–278 (doi:10.1016/j.cell.2022.11.001).CrossRefGoogle ScholarPubMed
Epel, E.S., Blackburn, E.H., Lin, J., Dhabhar, F.S., Adler, N.E., Morrow, J.D., Cawthon, R.M. 2004. Accelerated telomere shortening in response to life stress. Proc. Natl. Acad. Sci. USA 101, 17312–17315.CrossRefGoogle ScholarPubMed
Fiorito, G., Polidoro, S., Dugué, P.-A., Kivimaki, M., Ponzi, E., Matullo, G., Guarrera, S., Assumma, M.B., Georgiadis, P., Kyrtopoulos, S.A. 2017. Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation. Sci. Rep. 7, 16266.CrossRefGoogle Scholar
Ferrucci, L., Gonzalez-Freire, M., Fabbri, E., Simonsick, E., Tanaka, T., Moore, Z., Salimi, S., Sierra, F., de Cabo, R. 2020. Measuring biological aging in humans: a quest. Aging Cell 19, e13080 (doi:10.1111/acel.13080).CrossRefGoogle ScholarPubMed
Musi, N., Hornsby, P. 2021. Handbook of the Biology of Aging. Academic Press.Google Scholar

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