Book contents
- Frontmatter
- Contents
- Contributors
- Preface
- Bacterial Invasion of Host Cells
- 1 Invasion mechanisms of Salmonella
- 2 Shigella invasion
- 3 How Yersinia escapes the host: To Yop or not to Yop
- 4 Stealth warfare: The interactions of EPEC and EHEC with host cells
- 5 Molecular ecology and cell biology of Legionella pneumophila
- 6 Listeria monocytogenes invasion and intracellular growth
- 7 N. gonorrhoeae: The varying mechanism of pathogenesis in males and females
- 8 Group A streptococcal invasion of host cells
- 9 Invasion of oral epithelial cells by Actinobacillus actinomycetemcomitans
- 10 Invasion by Porphyromonas gingivalis
- Index
- Plate section
- References
4 - Stealth warfare: The interactions of EPEC and EHEC with host cells
Published online by Cambridge University Press: 21 August 2009
- Frontmatter
- Contents
- Contributors
- Preface
- Bacterial Invasion of Host Cells
- 1 Invasion mechanisms of Salmonella
- 2 Shigella invasion
- 3 How Yersinia escapes the host: To Yop or not to Yop
- 4 Stealth warfare: The interactions of EPEC and EHEC with host cells
- 5 Molecular ecology and cell biology of Legionella pneumophila
- 6 Listeria monocytogenes invasion and intracellular growth
- 7 N. gonorrhoeae: The varying mechanism of pathogenesis in males and females
- 8 Group A streptococcal invasion of host cells
- 9 Invasion of oral epithelial cells by Actinobacillus actinomycetemcomitans
- 10 Invasion by Porphyromonas gingivalis
- Index
- Plate section
- References
Summary
Although the Gram-negative bacterium Escherichia coli is normally considered to be a harmless commensal of the gastrointestinal flora, there are some exceptions to this rule. In the past few decades it has become increasingly evident that there are serotypes of E. coli that may cause disease in susceptible hosts. Disease states range from the invasive infections of the urinary tract caused by uropathogenic E. coli (UPEC) to the more typical diarrheal disease caused by several groups of E. coli serotypes, including enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC). There is an increasing realization that bacteria–host interactions with pathogenic E. coli are far more complex and intricate than originally imagined. Studying the ways that bacteria such as EHEC and EPEC are able to subvert host cell functions to their own ends can be thought of as a “window” through which we are able to view the inner workings of the eukaryotic cell. In this chapter we examine some of the mechanisms by which EHEC and EPEC are able to coerce their host; we also examine the sequelae of these interactions.
EPEC usually refers to E. coli serotypes O55:[H6], O86:H34, O111:[H2], O114:H2, O119:[H6], O127:H6, O142:H6, and O142:H34, where square brackets indicate the occurrence of nonmotile strains (Nataro and Kaper, 1998). Infection with EPEC typically causes a chronic watery diarrhea, accompanied by a low-grade fever and nausea.
- Type
- Chapter
- Information
- Bacterial Invasion of Host Cells , pp. 87 - 122Publisher: Cambridge University PressPrint publication year: 2004