Dietterlin and other Renaissance artists supported an empirical approach to architectural image-making, one that emerged in treatises like Dietterlin’s Architectura. Such treatises became sites of conflict between rationalist and empirical mathematical traditions, with Dietterlin’s mixed arithmetic and geometrical design procedures marking a pivotal turn toward empiricism. The development of prints in architectural texts – from geometrical illustrations in masonic incunables to Dürer’s 1525 Lesson on Measurement and archaeological renderings by Sebastiano Serlio, Philibert De L’Orme, and Hans Blum – shows how Dietterlin and his contemporaries increasingly rejected received knowledge in favor of the empirical epistemology also practiced by period artists and natural philosophers. As architectural treatises shifted from rationalist to empirical approaches to architectural design, they aligned architecture with the empirical culture of Renaissance image-making exemplified in Dietterlin’s Architectura.