The chapter presents the specific applied approach to HCI research, including an illustration from the literature. The latter explores interspecies sense-making in the context of dog-tracking and in the light of multi-species ethnography. The chapter presents the specific applied framework for HCI research comprising applied as discipline, general problem, particular scope, research, knowledge and practices. The specific applied framework is followed by the applied design research exemplar, as the applied design cycle and the applied design research cycle. The lower-level applied framework comprises the applied application, the applied interactive system, and the applied interactive system performance. Both the exemplar and the lower-level framework are applied to the same illustration of the applied approach taken from the literature, which explores interspecies sense-making in the context of dog-tracking and in the light of multi-species ethnography.