Apoptosis in health, disease, and therapy: overview and methodology

doi:10.1017/CBO9780511663543.002

1 - Apoptosis in health, disease, and therapy: overview and methodology

Published online by Cambridge University Press: 03 March 2010

Eric C. LaCasse ,

Martin Holcik ,

Robert G. Korneluk and

Alex E. MacKenzie

Edited by

Martin Holcik ,

Eric C. LaCasse ,

Alex E. MacKenzie and

Robert G. Korneluk

Show author details

Eric C. LaCasse: Affiliation:
Ægera Oncology Inc.
Martin Holcik: Affiliation:
Department of Pediatrics, University of Ottawa, Apoptosis Research Centre and the Solange Gauthier Karsh Molecular Genetics Laboratory, Children's Hospital of Eastern Ontario Research Institute
Robert G. Korneluk: Affiliation:
Departments of Pediatrics, and Biochemistry, Microbiology, and Immunology, University of Ottawa Apoptosis Research Centre and the Solange Gauthier Karsh Molecular Genetics Laboratory, Children's Hospital of Eastern Ontario Research Institute
Alex E. MacKenzie: Affiliation:
Department of Pediatrics, University of Ottawa, Apoptosis Research Centre and the Solange Gauthier Karsh Molecular Genetics Laboratory, Children's Hospital of Eastern Ontario Research Institute
Martin Holcik: Affiliation:
University of Ottawa
Eric C. LaCasse: Affiliation:
University of Ottawa
Alex E. MacKenzie: Affiliation:
University of Ottawa
Robert G. Korneluk: Affiliation:
University of Ottawa

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Summary

Introduction: life cannot exist without cellular death

Apoptosis, or programmed cell death, is the mechanism by which most cells die both physiologically and pathologically. The realization in the mid 1980s that cells die by an active, genetically defined process changed not only our views on cellular life but led to a whole new discipline of biologic study with significant implications for medicine (Thompson, 1995; Robertson et al., 2002). Apoptosis research has advanced our understanding of a basic cellular process, shed insight into many diseases, and is poised to affect the future practice of medicine by the introduction of therapies targeting this cell death process.

In this book, the term “apoptosis” is used synonymously, for right or wrong, with programmed cell death (PCD). While PCD may be a more appropriate term, encompassing all forms of active physiological cell death, apoptosis, which is defined morphologically and biochemically, is used here for historical purposes (Lockshin and Zakeri, 2002; Melino, 2002; Sloviter, 2002). The original “anatomical” characteristics of apoptosis were noted in the nineteenth century (reviewed in Clarke and Clarke, 1996; Rich et al., 1999). However, it was not until publications in 1951 and in the 1960s described developmental cell death or “shrinkage necrosis” that the PCD concept was recognized, re-introduced, and formalized (Lockshin and Zakeri, 2001; Kerr, 2002; Vaux, 2002). The term “apoptosis” was coined in 1972, referring to this morphologically defined form of cell death (Kerr et al., 1972).

Type: Chapter
Information: Apoptosis in Health and Disease
Clinical and Therapeutic Aspects
, pp. 1 - 48

DOI: https://doi.org/10.1017/CBO9780511663543.002 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2005

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