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4 - The Double-Jointed Fly

from Part II - Flies

Published online by Cambridge University Press:  26 February 2021

Lewis I. Held, Jr
Lewis I. Held, Jr
Affiliation:
Texas Tech University
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Summary

We start with an odd mutation in flies that causes their legs to be double-jointed, but what is even stranger is that the extra joints are upside-down. This leads to a discussion of cell polarity not only in flies but also in the inner ear of humans. Two intercellular signaling pathways are involved:PCP and Notch.

Keywords

legjointspolarityaxesinner earNotch pathwayboundary
Type
Chapter
Information
Animal Anomalies
What Abnormal Anatomies Reveal about Normal Development
 , pp. 53 - 64
Publisher: Cambridge University Press
Print publication year: 2021

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