The most widely utilized laser in ENT surgery is the carbon dioxide (CO2) laser. Total intravenous anesthesia (TIVA) techniques for laser ENT surgery are particularly popular, and are essential in cases where the patients are unintubated and jet ventilation is used. The otolaryngology and anesthesia teams will find it necessary to discuss the advantages and disadvantages of the various clinical options in the light of the patient's condition, the available equipment, and the preferences and training of the two clinical teams. Special laser endotracheal tubes are often employed. TIVA is usually carried out using a combination of propofol and remifentanil. Concerns about the possibility of tissue edema (especially after neodymium: yttrium-aluminum-garnet (Nd:YAG) laser use), pneumothorax, bleeding, and pneumomediastinum are also frequent postoperative issues. Extubation over a tube exchanger can be helpful in cases where the need for reintubation is a concern and would be expected to be challenging.