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Chapter 5 - Intrauterine Transfusion

from Section 1

Published online by Cambridge University Press:  19 November 2021

By
Saul Snowise  and
Ranu Jain
Edited by
Olutoyin A. Olutoye
Olutoyin A. Olutoye
Affiliation:
Ann & Robert H. Lurie Children's Hospital of Chicago, Illinois
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Summary

Hemolytic disease of the fetus and newborn is a common cause of intrauterine death and increased neonatal morbidity. While this condition may occur as a result of maternal antibody formation to a variety of different antibodies,(alloimmunization), that which occurs in response to the Rhesus D antigen is the most common. Many centers now perform intrauterine fetal blood transfusion, a required mode of therapy for alloimunization, which is necessary to prevent fetal demise. The ability to accurately detect and treat fetuses affected by this condition depends on adequate prenatal care, astute maternal-fetal practitioners, and a robust center with the ability to analyze fetal blood samples which directs transfusion therapy. While intrauterine therapy is not without complications, and is commonly characterized by repeated fetal transfusions, the ability to transfuse fetuses in-utero has drastically improved the prognosis for affected babies.

Keywords

Rhesus alloimmunizationmiddle cerebral arteryintrauterinetransfusion, antigenantibodieshemolysishemorrhagehemoglobinCoombs test
Type
Chapter
Information
Anesthesia for Maternal-Fetal Surgery
Concepts and Clinical Practice
 , pp. 64 - 82
Publisher: Cambridge University Press
Print publication year: 2021

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