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Chapter 5 - Intravenous Thrombolysis

Published online by Cambridge University Press:  28 October 2019

Mary Carter Denny ,
Ahmad Riad Ramadan ,
Sean I. Savitz  and
James Grotta
Mary Carter Denny
Affiliation:
Georgetown University Hospital
Ahmad Riad Ramadan
Affiliation:
Henry Ford Hospital, Detroit
Sean I. Savitz
Affiliation:
University of Texas Health Science Center, Houston
James Grotta
Affiliation:
Memorial Hermann Texas Medical School
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Summary

The only treatment that has been proven to improve outcome after ischemic stroke is to reperfuse the brain by removing the arterial obstruction. All animal and clinical studies show that brain tissue exposed to the reduced blood flow inherent after an arterial occlusion dies quickly, in proportion to the reduction of flow. Brain tissue where there is the most profound reduction of flow (the ischemic “core”) dies within minutes. In areas where flow is less severely reduced (the ischemic “penumbra”), tissue death occurs more gradually, dependent on the adequacy of collateral flow. The faster that normal flow can be re-established, the less tissue death and the less consequent disability occurs. This chapter deals with systemic thrombolysis.

Type
Chapter
Information
Acute Stroke Care , pp. 58 - 79
Publisher: Cambridge University Press
Print publication year: 2019

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