The relationship between academic freedom and knowledge production is examined in in this chapter. Various contested constructions of knowledge within and across the different geographical contexts and by discipline are critically interrogated, and the implications of these constructions are considered for pedagogy, research, and understanding of academic freedom. As such, conceptions of knowledge invoke particular conceptions of the value of education and its aims. This is examined in relation to neoliberal discourses of skills, impact and marketability, positionality, and decolonisation of knowledge initiatives. The temporal and geographical positionality of knowledge is critically interrogated, recognising the Western hegemony of knowledge and its production, calling for the need to situate knowledge sociopolitically and historically. This necessitates the recognition that academic freedom is similarly situated in space and time, with discussions of examples across the four national contexts. Debates surrounding the organisation and gatekeeping of knowledge through the disciplines and the rise of interdisciplinarity are also addressed in this chapter.