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10 - Interactions between Salmonella and dendritic cells: what happens along the way?

Published online by Cambridge University Press:  04 December 2009

Duncan Maskell
By
Cecilia Johansson ,
Malin Sundquist  and
Mary Jo Wick
Edited by
Pietro Mastroeni
Duncan Maskell
Affiliation:
University of Cambridge
Cecilia Johansson
Affiliation:
Department of Clinical Immunology, University of Goteborg, Guldhedsgatan 10A, Goteborg SE-413 46, Sweden
Malin Sundquist
Affiliation:
Department of Clinical Immunology, University of Goteborg, Guldhedsgatan 10A, Goteborg SE-413 46, Sweden
Mary Jo Wick
Affiliation:
Department of Clinical Immunology, University of Goteborg, Guldhedsgatan 10A, Goteborg SE-413 46, Sweden
Pietro Mastroeni
Affiliation:
University of Cambridge
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Summary

INTRODUCTION

Dendritic cells (DC) are efficient antigen-presenting cells and are likely to be involved in the initiation of T-cell responses to Salmonella. However, it is not known what type of DC initiate immune responses to Salmonella or where this initiation takes place. Studies on interactions between Salmonella and DC are emerging and are shedding light on this topic. This chapter will review how Salmonella interacts with DC, following the course the bacteria take after oral infection. One of the earliest sites of Salmonella replication is within the Peyer's patches of the gut. Thereafter, Salmonella can be found in the gut-draining mesenteric lymph nodes. After systemic release of bacteria or bacteria-containing cells, Salmonella spread to the spleen and liver and replicate further. The relevance of the interactions between Salmonella and DC in these organs for initiating antibacterial T-cell responses is discussed. This is preceded by a brief overview of the biology of DC.

DENDRITIC CELLS

DC originate from precursors in the bone marrow and were named because of their morphology having long, branched dendrites (Steinman and Cohn, 1973; Steinman et al., 1974). DC are widely distributed in lymphoid as well as non-lymphoid tissues (Steptoe et al., 2000; Vremec and Shortman, 1997; Steiniger et al., 1984).

Type
Chapter
Information
Salmonella Infections
Clinical, Immunological and Molecular Aspects
 , pp. 279 - 298
Publisher: Cambridge University Press
Print publication year: 2006

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