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Chapter 1.2 - Chapter

from 1 - Inflammatory Conditions

Published online by Cambridge University Press:  06 October 2022

Anita Arsovska
Affiliation:
University of Ss Cyril and Methodius
Derya Uluduz
Affiliation:
Istanbul Üniversitesi
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Summary

Vogt Koyanagi Harada (VKH) disease is an idiopathic autoimmune disease primarily manifesting as bilateral, chronic, and diffuse granulomatous panuveitis associated with auditory, neurological, and integumentary findings. Clinical suspicious of VKH is female dominance, flu-like symptoms with meningismus preceding acute blurring of vision, ocular disease, recurrent aseptic meningitis with or without focal neurologic findings, sunset glow fundus. Patients has four clinical stages; prodromal or early stage, uveitic stage, convalescent stage which is characterized by depigmentation of the choroid, hair and skin, and chronic stage usually occurs in the first six months. The emergency or primary care physician may be the point of first contact with a patient with VKH disease. The key components of managing this disease are awareness of symptoms that lead to early diagnosis and a multidisciplinary approach. For patients with severe visual loss and bilateral serous retinal detachments, systemic prednisolone at 1-2mg/kg/day is started

Type
Chapter
Information
Rare Causes of Stroke
A Handbook
, pp. 50 - 53
Publisher: Cambridge University Press
Print publication year: 2022

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References

Shruthi, P, Sridhar, A, Sharath Kumar, G. Case of the week: Vogt-Koyanagi-Harada syndrome (VKH). Am J Neuroradiol. 2018. www.ajnr.org/content/cow/12062018 (accessed January 2022).Google Scholar
Yang, P, Ren, Y, Li, B, et al. Clinical characteristics of Vogt-Koyanagi-Harada syndrome in Chinese patients. Ophthalmology. 2007;114: 606614.CrossRefGoogle ScholarPubMed
Lavezzo, MM, Sakata, VM, Morita, C, et al. Vogt-Koyanagi-Harada disease: Review of a rare autoimmune disease targeting antigens of melanocytes. Orphanet J Rare Dis. 2016;11: 29.CrossRefGoogle ScholarPubMed
Patil, YB, Garg, R, Rajguru, JP, et al. Vogt-Koyanagi-Harada (VKH) syndrome: A new perspective for healthcare professionals. J Family Med Prim Care. 2020;9: 3135.Google ScholarPubMed
Yang, P, Zhong, Y, Du, L, et al. Development and evaluation of diagnostic criteria for Vogt-Koyanagi-Harada disease. JAMA Ophthalmol. 2018;136: 10251031.CrossRefGoogle ScholarPubMed

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  • Chapter
  • Edited by Derya Uluduz, Istanbul Üniversitesi
  • Anita Arsovska
  • Book: Rare Causes of Stroke
  • Online publication: 06 October 2022
  • Chapter DOI: https://doi.org/10.1017/9781108902793.010
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  • Chapter
  • Edited by Derya Uluduz, Istanbul Üniversitesi
  • Anita Arsovska
  • Book: Rare Causes of Stroke
  • Online publication: 06 October 2022
  • Chapter DOI: https://doi.org/10.1017/9781108902793.010
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Chapter
  • Edited by Derya Uluduz, Istanbul Üniversitesi
  • Anita Arsovska
  • Book: Rare Causes of Stroke
  • Online publication: 06 October 2022
  • Chapter DOI: https://doi.org/10.1017/9781108902793.010
Available formats
×