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18 - Acute Decompensated Heart Failure

from Section 4 - Cardiovascular Emergencies

Published online by Cambridge University Press:  02 November 2023

Kaushal Shah
Affiliation:
Weill Cornell Medical Center, New York
Jarone Lee
Affiliation:
Massachusetts General Hospital, Boston
Clark G. Owyang
Affiliation:
Weill Cornell Medical Center, New York
Benjamin Christian Renne
Affiliation:
Massachusetts General Hospital, Boston
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Summary

  • Heart failure (HF) is a clinical syndrome marked by elevated filling pressures to maintain acceptable cardiac output. Current guidelines use left ventricular ejection fraction (LVEF) to distinguish between reduced (HFrEF; LVEF < 40%), preserved (HFpEF; LVEF > 50%) and midrange ejection fractions (HFmrEF; LVEF between 40–49%).

  • Beta blockers, angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor neprilysin inhibitors (ARNI), sodium-glucose transporter-2 (SGLT2) inhibitors and cardiac resynchronization therapy, among other therapies, improve outcomes in HFrEF. HFpEF management focuses on comorbidity management with recent data showing benefit from SGLT-2 inhibitor, empagliflozin.

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Publisher: Cambridge University Press
Print publication year: 2023

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References

Berbenetz, N, Wang, Y, Brown, J, et al. Non-invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary oedema. Cochrane Database Syst Rev 2019;4(4):CD005351. https://doi.org/10.1002/14651858.CD005351.pub4Google ScholarPubMed
Ponikowski, P, Voors, AA, Anker, SD, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC [published correction appears in Eur Heart J 2016 Dec 30]. Eur Heart J 2016;37(27):21292200. https://doi.org/10.1093/eurheartj/ehw128CrossRefGoogle Scholar
Wang, K, & Samai, K. Role of high-dose intravenous nitrates in hypertensive acute heart failure. Am J Emerg Med 2020;38(1):132137. https://doi.org/10.1016/j.ajem.2019.06.046CrossRefGoogle ScholarPubMed
Yancy, CW, Jessup, M, Bozkurt, B, et al. 2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. Circulation. 2017;136(6):e137-e161. https://doi.org/10.1161/CIR.0000000000000509CrossRefGoogle Scholar
Yancy, CW, Jessup, M, Bozkurt, B, et al. 2013 ACCF/AHA guideline for the management of heart failure: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2013;62(16):e147e239. https://doi.org/10.1016/j.jacc.2013.05.019CrossRefGoogle Scholar

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