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Chapter 17 - Interventions to Prevent DOHaD Effects in Pregnancy

from Section V - Interventions

Published online by Cambridge University Press:  01 December 2022

Lucilla Poston
Affiliation:
King's College London
Keith M. Godfrey
Affiliation:
University of Southampton
Peter D. Gluckman
Affiliation:
University of Auckland
Mark A. Hanson
Affiliation:
University of Southampton
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Summary

Numerous observational studies in mother-child cohorts have identified associations between adverse fetal exposures in utero and persistent consequences for the child in later life. These have prompted multiple randomized controlled trials (RCTs) in pregnant women to evaluate whether reversal of these exposures has the expected benefit for the health of the child. In this narrative review, the major categories of RCTs undertaken are introduced, and the outcomes addressed. In light of a preponderance of negative studies, reasons are explored including inadequacies in trial design and the rationale for intervening before conception, during pregnancy and after pregnancy.

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Publisher: Cambridge University Press
Print publication year: 2022

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