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13B - Corticosteroid Therapy Is Useful in Assisting Implantation

Against

from Section II - IVF Add-ons

Published online by Cambridge University Press:  25 November 2021

Roy Homburg
Affiliation:
Homerton University Hospital, London
Adam H. Balen
Affiliation:
Leeds Centre for Reproductive Medicine
Robert F. Casper
Affiliation:
Mount Sinai Hospital, Toronto
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Summary

The crucial factors needed to achieve an efficacious and efficient IVF treatment include the maximisation of the ovarian response to the stimulation, the optimisation of endometrial receptivity, the minimisation of IVF-related risks and the improvement of lab technologies. There has been a continuously growing interest in determining drugs with the potential to improve outcomes after IVF. In the last decades many adjuvant therapies have been proposed but strong evidence to support their role in improving clinical results is still missing. Moreover their side effects are still unclear. Based on this scenario, corticosteroids have been proposed to enhance embryo implantation and reduce miscarriage in ART patients. In this manuscript we briefly analyse and comment on the scientific evidence in literature investigating the purpose of corticosteroids and its effectiveness throughout embryo implantation. Both the beneficial and potentially harmful effects will be discussed thoroughly.

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Chapter
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Publisher: Cambridge University Press
Print publication year: 2021

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References

Simón, C, Dominguez, F, Remohi, J, Pellicer, A. Embryo effects in human implantation: embryonic regulation of endometrial molecules in human implantation. Ann NY Acad Sci. 2001 Sept;943:116.CrossRefGoogle ScholarPubMed
Glujovsky, D, Farquhar, C, Quinteiro Retamar, AM, Alvarez Sedo, CR, Blake, D. Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology. Cochrane Database of Systematic Reviews 2016, Issue 6. Art. No.: CD002118.CrossRefGoogle Scholar
Capalbo, A, Hoffmann, ER, Cimadomo, D, Ubaldi, FM, Rienzi, L. Human female meiosis revised: new insights into the mechanisms of chromosome segregation and aneuploidies from advanced genomics and time-lapse imaging. Hum Reprod Update. 2017 Nov 1;23(6):706–22.CrossRefGoogle ScholarPubMed
Romanelli, V, Poli, M, Capalbo, A. Preimplantation genetic testing in assisted reproductive technology. Panminerva Med. 2019;61:3041.CrossRefGoogle ScholarPubMed
Macklon, N, Brosens, J. The human endometrium as a sensor of embryo quality. Biol Reprod. 2014;91(4):98, 1–8.CrossRefGoogle ScholarPubMed
Robertson, SA, Jin, M, Yu, D, et al. Corticosteroid therapy in assisted reproduction-immune suppression is a faulty premise. Hum Reprod. 2016;31(10):2164–73.CrossRefGoogle Scholar
Boomsma, CM, Keay, SD, Macklon, NS. Peri-implantation glucocorticoid administration for assisted reproductive technology cycles. Cochrane Database of Systematic Reviews 2012, Issue 6. Art. No.: CD005996.CrossRefGoogle Scholar

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