Book contents
- 50 Big Debates in Gynecologic Oncology
- 50 Big Debates in Gynecologic Oncology
- Copyright page
- Contents
- Contributors
- Section I Perioperative Management
- Section II Screening, Prevention, and Early Diagnosis
- Debate 3A Should Women with BRCA Mutations be Offered Bilateral Salpingectomy with Delayed Oophorectomy for Ovarian Cancer Risk Reduction?
- Chapter 3B Should Women with BRCA Mutations be Offered Bilateral Salpingectomy with Delayed Oophorectomy for Ovarian Cancer Risk Reduction?
- Debate 4A Can High-risk HPV Testing be Used Alone as the Primary Screening Modality for Cervical Cancer?
- Debate 4B Can High-risk HPV Testing be Used Alone as the Primary Screening Modality for Cervical Cancer?
- Section III Ovarian Cancer
- Section IV Endometrial Cancer
- Section V Cervical Cancer
- Section VI Vaginal and Vulvar Cancer
- Index
- References
Chapter 3B - Should Women with BRCA Mutations be Offered Bilateral Salpingectomy with Delayed Oophorectomy for Ovarian Cancer Risk Reduction?
No
from Section II - Screening, Prevention, and Early Diagnosis
Published online by Cambridge University Press: 20 July 2023
Book contents
- 50 Big Debates in Gynecologic Oncology
- 50 Big Debates in Gynecologic Oncology
- Copyright page
- Contents
- Contributors
- Section I Perioperative Management
- Section II Screening, Prevention, and Early Diagnosis
- Debate 3A Should Women with BRCA Mutations be Offered Bilateral Salpingectomy with Delayed Oophorectomy for Ovarian Cancer Risk Reduction?
- Chapter 3B Should Women with BRCA Mutations be Offered Bilateral Salpingectomy with Delayed Oophorectomy for Ovarian Cancer Risk Reduction?
- Debate 4A Can High-risk HPV Testing be Used Alone as the Primary Screening Modality for Cervical Cancer?
- Debate 4B Can High-risk HPV Testing be Used Alone as the Primary Screening Modality for Cervical Cancer?
- Section III Ovarian Cancer
- Section IV Endometrial Cancer
- Section V Cervical Cancer
- Section VI Vaginal and Vulvar Cancer
- Index
- References
Summary
The hope that we can prevent ovarian cancer in women at high risk by removing their fallopian tubes while leaving their ovaries intact is based on the belief that many, if not most, high-grade serous ovarian cancers originate in the tubes. The current recommendation for surgical prevention is bilateral salpingo-oophorectomy (BSO). Salpingectomy alone is not yet the standard of care for women with a BRCA1 of BRCA2 mutation, but is being proposed widely and is offered in many centers.
- Type
- Chapter
- Information
- 50 Big Debates in Gynecologic Oncology , pp. 13 - 15Publisher: Cambridge University PressPrint publication year: 2023
References
Bowtell, DD, et al. Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer. Nat Rev Cancer 2015;15(11):668–679.CrossRefGoogle ScholarPubMed
Kotsopoulos, J, et al. Hereditary Ovarian Cancer Clinical Study Group. Breastfeeding and the risk of epithelial ovarian cancer among women with a BRCA1 or BRCA2 mutation. Gynecol Oncol 2020;2020:S0090–8258.Google Scholar
Gronwald, J, et al. A comparison of ovarian cancer mortality in women with BRCA1 mutations undergoing annual ultrasound screening or preventive oophorectomy. Gynecol Oncol 2019;155(2):270–274. https://doi.org/10.1016/j.ygyno.2019.08.034CrossRefGoogle ScholarPubMed
Finch, AP, et al. Impact of oophorectomy on cancer incidence and mortality in women with a BRCA1 or BRCA2 mutation. J Clin Oncol 2014;32(15):1547–1553.CrossRefGoogle ScholarPubMed
Metcalfe, K, et al. Effect of oophorectomy on survival after breast cancer in BRCA1 and BRCA2 mutation carriers. JAMA Oncol 2015;1(3):306–313.CrossRefGoogle ScholarPubMed
Evans, DG, et al. Survival from breast cancer in women with a BRCA2 mutation by treatment. Br J Cancer 2021;124(9):1524–1532.CrossRefGoogle ScholarPubMed
Lugo Santiago, N, et al. Ovarian cancer after prophylactic salpingectomy in a patient with germline BRCA1 mutation. Obstet Gynecol 2020;135(6):1270–1274. https://doi.org/10.1097/AOG.0000000000003864CrossRefGoogle Scholar