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Chapter 3B - Should Women with BRCA Mutations be Offered Bilateral Salpingectomy with Delayed Oophorectomy for Ovarian Cancer Risk Reduction?

No

from Section II - Screening, Prevention, and Early Diagnosis

Published online by Cambridge University Press:  20 July 2023

By
Steven A. Narod
Edited by
Dennis S. Chi ,
Nisha Lakhi  and
Nicoletta Colombo
Dennis S. Chi
Affiliation:
Memorial Sloan-Kettering Cancer Center, New York
Nisha Lakhi
Affiliation:
Richmond University Medical Center, Staten Island
Nicoletta Colombo
Affiliation:
University of Milan-Bicocca
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Summary

The hope that we can prevent ovarian cancer in women at high risk by removing their fallopian tubes while leaving their ovaries intact is based on the belief that many, if not most, high-grade serous ovarian cancers originate in the tubes. The current recommendation for surgical prevention is bilateral salpingo-oophorectomy (BSO). Salpingectomy alone is not yet the standard of care for women with a BRCA1 of BRCA2 mutation, but is being proposed widely and is offered in many centers.

Type
Chapter
Information
50 Big Debates in Gynecologic Oncology , pp. 13 - 15
Publisher: Cambridge University Press
Print publication year: 2023

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References

Bowtell, DD, et al. Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer. Nat Rev Cancer 2015;15(11):668–679.CrossRefGoogle ScholarPubMed
Kotsopoulos, J, et al. Hereditary Ovarian Cancer Clinical Study Group. Breastfeeding and the risk of epithelial ovarian cancer among women with a BRCA1 or BRCA2 mutation. Gynecol Oncol 2020;2020:S0090–8258.Google Scholar
Gronwald, J, et al. A comparison of ovarian cancer mortality in women with BRCA1 mutations undergoing annual ultrasound screening or preventive oophorectomy. Gynecol Oncol 2019;155(2):270–274. https://doi.org/10.1016/j.ygyno.2019.08.034CrossRefGoogle ScholarPubMed
Finch, AP, et al. Impact of oophorectomy on cancer incidence and mortality in women with a BRCA1 or BRCA2 mutation. J Clin Oncol 2014;32(15):1547–1553.CrossRefGoogle ScholarPubMed
Metcalfe, K, et al. Effect of oophorectomy on survival after breast cancer in BRCA1 and BRCA2 mutation carriers. JAMA Oncol 2015;1(3):306–313.CrossRefGoogle ScholarPubMed
Evans, DG, et al. Survival from breast cancer in women with a BRCA2 mutation by treatment. Br J Cancer 2021;124(9):1524–1532.CrossRefGoogle ScholarPubMed
Lugo Santiago, N, et al. Ovarian cancer after prophylactic salpingectomy in a patient with germline BRCA1 mutation. Obstet Gynecol 2020;135(6):1270–1274. https://doi.org/10.1097/AOG.0000000000003864CrossRefGoogle Scholar

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