Skip to main content Accessibility help
×
Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-29T14:09:02.875Z Has data issue: false hasContentIssue false

8A - There Is a Role for Pre-conceptional Treatment with CoQ10

For

from Section II - IVF Add-ons

Published online by Cambridge University Press:  25 November 2021

Roy Homburg
Affiliation:
Homerton University Hospital, London
Adam H. Balen
Affiliation:
Leeds Centre for Reproductive Medicine
Robert F. Casper
Affiliation:
Mount Sinai Hospital, Toronto
Get access

Summary

Making evidence-based decisions with a common primary outcome measure is a key tenet of ethical and effective clinical practice in ART in a rapidly evolving scientific landscape. However, interpretation of the evidence must be underpinned by sound biological reasoning, and this is especially true when it comes to adjunct antioxidant supplementation in IVF. Furthermore, study design for assessing natural compounds is typically based on protocols established to assess drug-based therapies that often fail to effectively evaluate efficacy of individual nutrients that occur naturally in vivo and often groups study patients together with many differing aetiologies. Finally, the gold standard in terms of IVF outcome measure is live birth rate (LBR), but it is vital that we move beyond this narrow perspective and consider obstetric and child health outcomes. With this in mind I will describe the role for pre-conceptional treatment with CoQ10.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2021

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ramalho-Santos, R, Varum, S, Amaral, S, et al. Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells. Hum Reprod. Update 2009;15(5):553–72.CrossRefGoogle ScholarPubMed
Díaz-Casado, ME, Quiles, JL, Barriocanal-Casado, E, et al. The paradox of coenzyme Q10 in aging. Nutrients. 2019;11(9):2221.CrossRefGoogle ScholarPubMed
Ben-Meir, A, Yahalomi, S, Moshe, B, Shufaro, Y, Reubinoff, B, Saada, A. Coenzyme Q-dependent mitochondrial respiratory chain activity in granulosa cells is reduced with aging. Fertil Steril. 2015;104(3):724–7.CrossRefGoogle ScholarPubMed
Bentov, Y, Hannam, T, Jurisicova, A, Esfandiari, N, Casper, RF. Coenzyme Q10 supplementation and oocyte aneuploidy in women undergoing IVF-ICSI treatment. Clin Med Insights Reprod Health. 2014;8:31–6.CrossRefGoogle ScholarPubMed
Zhang, Y, Zhang, C, Shu, J, et al. Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis. Hum Reprod Update. 2020;26(2):247–63.CrossRefGoogle ScholarPubMed
Xu, Y, Nisenblat, V, Lu, C, et al. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial. Reprod Biol Endocrinol. 2018;16(1):29.CrossRefGoogle ScholarPubMed
Florou, P, Anagnostis, P, Theocharis, P, Chourdakis, M, Goulis, D. Does coenzyme Q10 supplementation improve fertility outcomes in women undergoing assisted reproductive technology procedures? A systematic review and meta-analysis of randomized-controlled trials. J Assist Reprod Genet. 2020;37(10):2377–87.CrossRefGoogle ScholarPubMed
Hernández-Camacho, JD, Bernier, M, López-Lluch, G, Navas, P. Coenzyme Q10 supplementation in aging and disease. Front Physiol. 2018;9.CrossRefGoogle ScholarPubMed
Fan, L, Feng, Y, Chen, GC, Qin, LQ, Fu, CL, Chen, LH. Effects of coenzyme Q10 supplementation on inflammatory markers: a systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2017;119:128–36.CrossRefGoogle ScholarPubMed
Stephenson, J, Heslehurst, N, Hall, J, et al. Before the beginning: nutrition and lifestyle in the preconception period and its importance for future health. The Lancet. 2018;391:10132.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×