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16A - The Freezing of All Embryos Should Be Used for All IVF Cycles

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from Section III - The Best Policy

Published online by Cambridge University Press:  25 November 2021

Roy Homburg
Affiliation:
Homerton University Hospital, London
Adam H. Balen
Affiliation:
Leeds Centre for Reproductive Medicine
Robert F. Casper
Affiliation:
Mount Sinai Hospital, Toronto
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Summary

Although there are many potential advantages associated with performing a freeze-all cycle over fresh ET, it seems that the freeze-all strategy is not designed for all of IVF patients. Based on the findings of available RCTs, it seems reasonable to implement this strategy in patients with a risk of OHSS, hyper-responders/PCOS patients, and when performing PGT in the blastocyst stage. Further, RCTs are needed to evaluate the appropriateness of the freeze-all strategy for all other possible indications. Thus, implementation of the freeze-all strategy should be individualised and offered to all patients who would most likely benefit from it.

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Chapter
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Publisher: Cambridge University Press
Print publication year: 2021

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References

Devroey, P, Polyzos, NP, Blockeel, C. An OHSS-free clinic by segmentation of IVF treatment. Hum Reprod. 2011;26:2593–7.CrossRefGoogle ScholarPubMed
Roque, M, Haahr, T, Geber, S, Esteves, SC, Humaidan, P. Fresh versus elective frozen embryo transfer in IVF/ICSI cycles: A systematic review and meta-analysis of reproductive outcomes. Hum Reprod Update. 2019;25:214.CrossRefGoogle ScholarPubMed
Blockeel, C, Campbell, A, Coticchio, G, et al. Should we still perform fresh embryo transfers in ART? Hum Reprod. 2019; 34: 2319–29.CrossRefGoogle ScholarPubMed
Maheshwari, A, Pandey, S, Raja, EM, Shetty, A, Hamilton, M, Bhattacharya, S. Is frozen embryo transfer better for mothers and babies? Can cumulative meta-analysis provide a definitive answer? Hum Reprod Update. 2018;24:35–8.CrossRefGoogle ScholarPubMed
Roque, M, Bedoschi, G, Cecchino, GN, Esteves, SC. Fresh versus frozen blastocyst transfer. Lancet. 2019;394:1227–18.CrossRefGoogle ScholarPubMed

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