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Single-agent PARP Inhibitor
from Section III - Ovarian Cancer
Published online by Cambridge University Press: 20 July 2023
Maintenance therapy with oral PARP inhibitors has been demonstrated to significantly expand the progression-free survival of patients with advanced HGSOC in response to front-line platinum-based chemotherapy. Currently, three options have been approved for patients with BRCAmut tumors (Olaparib, niraparib, or Olaparib-bevacizumab) and two options for patients with BRCAwt/HRD tumors (niraparib or Olaparib and bevacizumab). The reason for the controversy we are discussing in this chapter is the lack of evidence from randomized trials comparing single-agent PARPi versus PARP-i combined with bevacizumab. Both strategies have shown similar benefits in the hazard ratio, but medians are not comparable due to the different patient populations included and differences in tumor assessment. Nevertheless, several arguments support the single-PARPi option as the preferred one.
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